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ProteomicsCryo-EM structure of the human COP1-DET1 ubiquitin ligase complex
Ubiquitin modification regulates fundamental cellular processes by controlling protein stability and function. The ubiquitin ligase COP1, conserved from plants to humans, targets developmental transcription factors. COP1 can act on its own or be incorporated into CULLIN4–RING ligase (CRL4) complexes...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD071633 | Pride
Human Cop1-det1 ubiquitin ligase Cx-ms 
Transcriptomicsphotomorphogenesis-Expression profile of DET1-1 mutant during photomorphogenesis
rs09-01_det1 - photomorphogenesis - - Identification of the genes deregulated in det1-1 when seedlings grow in light or in dark (dark increase morphological differences between det1-1 and wild-type) - Expression profile of seedlings grown in dark then exposed to light - etiolated seedlings (5days) a...
ORGANISM(S): Arabidopsis thaliana 
2010-04-30 | E-GEOD-19843 | biostudies-arrayexpress
TranscriptomicsArabidopsis De-etiolated 1 Represses Photomorphogenesis by Positively Regulating Phytochrome Interacting Factors in the Dark
Arabidopsis seedlings undergo photomorphogenic development even in darkness when the function of De-etiolated 1 (DET1), a repressor of photomorphogenesis, is disrupted. Our results indicate that DET1 directly interacts with a group of transcription factors known as the phytochrome-interacting factor...
ORGANISM(S): Arabidopsis thaliana 
2015-03-19 | E-GEOD-60835 | biostudies-arrayexpress
GenomicsInactivation of DET1 causes neurological defects and lethality in mice and humans I
Inactivation of DET1 causes neurological defects and lethality in mice and humans I
PRJNA1133052 | ENA
UnknownDET1 dynamics underlie cooperative ubiquitination by CRL4<sup>DET1-COP1</sup> complexes.
Not available
S-EPMC11864197 | biostudies-literature
GenomicsDET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis
DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis
PRJNA449909 | ENA
GenomicsInactivation of DET1 causes neurological defects and lethality in mice and humans II
Inactivation of DET1 causes neurological defects and lethality in mice and humans II
PRJNA1133057 | ENA
Transcriptomicsphotomorphogenesis-Expression profile of DET1-1 mutant during photomorphogenesis
rs09-01_det1 - photomorphogenesis - - Identification of the genes deregulated in det1-1 when seedlings grow in light or in dark (dark increase morphological differences between det1-1 and wild-type) - Expression profile of seedlings grown in dark then exposed to light - etiolated seedlings (5days) a...
ORGANISM(S): Arabidopsis thaliana 
2010-05-01 | GSE19843 | GEO
GenomicsDET1-mediated COP1 regulation avoids HY5 activity over second-site targets to tune plant photomorphogenesis
DET1-mediated COP1 regulation avoids HY5 activity over second-site targets to tune plant photomorphogenesis
PRJNA648851 | ENA
GenomicsDET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis [RNA-seq]
DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis [RNA-seq]
PRJNA449911 | ENA
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