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ProteomicsThe deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma
Serum monoclonal immunoglobulin (Ig) is the main diagnostic factor for patients with multiple myeloma (MM), however its prognostic potential remains unclear. On a large MM patient cohort (n=4146), we observe no correlation between serum Ig levels and patient survival, while amount of intracellular I...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037309 | Pride
Multiple myeloma Deubiquitinase otud1 
ProteomicsEndothelial OTUD1 promotes Ang II-induced vascular remodeling by deubiquitinating SMAD3
Understanding the molecular mechanisms of pathological vascular remodeling is important for treating cardiovascular diseases and complications. Recent studies have highlighted a role of deubiquitinases in vascular pathophysiology. In this study, we investigated the role of a deubiquitinase, OTUD1, i...
ORGANISM(S): Homo sapiens (Human) 
2022-12-24 | PXD037926 | Pride
Huvec  lc-ms/ms 
GenomicsThe deubiquitinase OTUD1 attenuates periodontal inflammation by restricting neutrophil protein transport
The deubiquitinase OTUD1 attenuates periodontal inflammation by restricting neutrophil protein transport
PRJNA894293 | ENA
UnknownThe deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling.
Not available
S-EPMC8803853 | biostudies-literature
UnknownThe deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity.
Not available
S-EPMC7857436 | biostudies-literature
GenomicsThe deubiquitinase OTUD1 orchestrates cisplatin chemosensitivity of non-small cell lung cancer through destabilizing RAD23B/XPC
The deubiquitinase OTUD1 orchestrates cisplatin chemosensitivity of non-small cell lung cancer through destabilizing RAD23B/XPC
PRJNA1255496 | ENA
UnknownThe deubiquitinase OTUD1 stabilizes NRF2 to alleviate hepatic ischemia/reperfusion injury.
Not available
S-EPMC11340619 | biostudies-literature
UnknownThe Deubiquitinase OTUD1 Suppresses Secretory Neutrophil Polarization And Ameliorates Immunopathology of Periodontitis.
Not available
S-EPMC10602526 | biostudies-literature
TranscriptomicsThe deubiquitinase OTUD1 orchestrates cisplatin chemosensitivity of non-small cell lung cancer through destabilizing RAD23B/XPC
Lung cancer, especially the subgroup non-small cell lung cancer (NSCLC), continues to be one of the most commonly diagnosed cancers and the leading cause of cancer-related deaths worldwide. Cisplatin has long been a cornerstone of chemotherapy and has improved the prognosis for NSCLC patients. Howev...
ORGANISM(S): Homo sapiens 
2025-11-21 | GSE295626 | GEO
UnknownPleiotropic Roles of a KEAP1-Associated Deubiquitinase, OTUD1.
Not available
S-EPMC9952104 | biostudies-literature
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