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Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
UnknownManganese-Catalysed Deuterium Labelling of Anilines and Electron-Rich (Hetero)Arenes.
Not available
S-EPMC9322005 | biostudies-literature
TranscriptomicsTranscription profiling of Arabidopsis after deuterium oxide treatment
2H2O has a long history as a protein or amino acid labeling techinique, and such labeling systems have proven effective for many different types of studies. A disadvantage of a 2H2O labeling system is that plant growth is inhibited as the percentage of deuterium in the medium increases. However the ...
ORGANISM(S): Arabidopsis thaliana 
2009-09-25 | E-GEOD-18153 | biostudies-arrayexpress
UnknownBenzylic deuteration of alkylnitroaromatics via amine-base catalysed exchange with deuterium oxide.
Not available
S-EPMC10107807 | biostudies-literature
UnknownMolecular imaging of extracellular vesicles in vitro via Raman metabolic labelling.
Not available
S-EPMC7610785 | biostudies-literature
ProteomicsDeuterium oxide labeling methods for bulk and single muscle protein synthesis measures, and measures of integrated muscle protein synthesis and breakdown rates
This methodological pilot study explored the feasibility of an integrated tracer approach for simultaneous measurement of human skeletal muscle protein synthesis and breakdown during prolonged deuterium oxide (²H₂O) labelling. Four healthy men completed a five week protocol combining daily oral ²H₂O...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD078552 | Pride
Human Skeletal muscle Protein trunover 
ProteomicsANGPTL3/8 is an atypical unfoldase that regulates intravascular lipolysis by catalyzing unfolding of lipoprotein lipase as measured by hydrogen/deuterium exchange mass spectrometry (HDX-MS)
Lipoprotein lipase (LPL) carries out the lipolytic processing of triglyceride-rich lipoproteins (TRL) along the luminal surface of capillaries. LPL activity is regulated by angiopoietin-like proteins (ANGPTL3, ANGPTL4, and ANGPTL8), which control the delivery of TRL-derived lipid nutrients to tissue...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-03-26 | PXD060125 | Pride
Gpihbp1 Angptl3/8 Lipoprotein lipase Intravascular lipolysis Hdx-ms 
ProteomicsAmino acid and heavy water labelling to obtain protein turnover rates in intact adult animals
Both labelling studies were conducted with C57/BL6J adult male mice, derived from the same supplier and maintained under identical conditions. Eleven adult male C57BL/6JOlaHsd mice (Harlan UK Ltd., Shardlow, UK) of over 12 months of age at the start of the experiment were housed individually in 48 x...
ORGANISM(S): Mus Musculus (mouse) 
2021-12-13 | PXD029639 | JPOST Repository
ProteomicsD2O proteome dynamics in response to energy deficit
Energy deficit has shaped human evolution, and represents a potent physiological stressor associated with improvements in lifespan and healthspan in several species. Preserving locomotive capacity has likely been essential for food procurement and survival from starvation during the hunter-gatherer ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-04 | PXD061267 | Pride
Human Deuterium oxide labelling Skeletal muscle Lc-ms/ms 
TranscriptomicsCollagen Dynamics and Transcriptional Profiling in Bleomycin-induced Pulmonary Fibrosis
Collagen deposition is a key process during idiopathic pulmonary fibrosis (IPF); however, little is known about the dynamics of collagen formation during disease development. Tissue samples of early stages of human disease are not readily available and it is difficult to identify changes in collagen...
ORGANISM(S): Mus musculus 
2013-05-26 | E-GEOD-37635 | biostudies-arrayexpress
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