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ProteomicsRetina-Targeted 17β-Estradiol by the DHED Prodrug Rescues Visual Function and Actuates Neuroprotective Protein Net-works after Optic Nerve Crush in a Rat Model of Surgical Menopause. Katalin Prokai-Tatrai, Khadiza Zaman, Ammar Kapic, Kelleigh Hogan , Gabriela Sanchez-Rodriguez, Anna E. Silverio Vien Nguyen , Laszlo Prokai and Andrew J. Feola
The association between 17β-estradiol (E2) deprivation, seen in menopause and a risk for devel-oping glaucoma, has been shown. Thus, exogenous supplementation of E2 may protect against retinal ganglion cell (RGC) degradation and vision loss. Here, we investigated the utility of topical 10β,17β-dihyd...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-07 | PXD059520 | Pride
Bioinformatics  dhed  estrogen  glaucoma  menopause  optic nerve crush  optomotor response  protein–protein interaction networks  quantitative label-free retina proteomics 
ProteomicsProteomics-Based Retinal Target Engagement Analysis and Retina-Targeted Delivery of 17β-Estradiol by the DHED Prodrug in Males. Katalin Prokai-Tatrai,* Khadiza Zaman, Vien Nguyen, Daniel L. De La Cruz and Laszlo Prokai
We examined the impact of 17β-estradiol (E2) eye drops on the modulation of the proteome pro-file in the male rat retina. With discovery-driven proteomics, we have identified proteins that were regulated by the treatment. These proteins were assembled to several bioinformatics-based networks implica...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-11-04 | PXD027902 | Pride
Prote-omics Isotope-dilution Targeted proteomics Dhed prodrug Neuroprotection  lc-ms/ms 17β-estradiol  e2  eye drops  male retina  parallel-reaction monitoring 
UnknownRetina-Targeted Delivery of 17β-Estradiol by the Topically Applied DHED Prodrug.
Not available
S-EPMC7284430 | biostudies-literature
UnknownThe prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders.
Not available
S-EPMC4591937 | biostudies-literature
UnknownProteomics-Based Retinal Target Engagement Analysis and Retina-Targeted Delivery of 17β-Estradiol by the DHED Prodrug for Ocular Neurotherapy in Males.
Not available
S-EPMC8466286 | biostudies-literature
UnknownRetina-Targeted 17β-Estradiol by the DHED Prodrug Rescues Visual Function and Actuates Neuroprotective Protein Networks After Optic Nerve Crush in a Rat Model of Surgical Menopause.
Not available
S-EPMC11899211 | biostudies-literature
UnknownTreatment with brain specific estrogen prodrug ameliorates cognitive effects of surgical menopause in mice.
Not available
S-EPMC11330726 | biostudies-literature
UnknownTreatment with a brain-selective prodrug of 17β-estradiol improves cognitive function in Alzheimer's disease mice by regulating klf5-NF-κB pathway.
Not available
S-EPMC7260153 | biostudies-literature
Unknown10β,17α-Dihydroxyestra-1,4-dien-3-one: A Bioprecursor Prodrug Preferentially Producing 17α-Estradiol in the Brain for Targeted Neurotherapy.
Not available
S-EPMC6582959 | biostudies-literature
ProteomicsBypassing Androgens: CNS-Targeted Estrogen Delivery Res-cues the Gonadectomized Male Rat Visual Cortex Neuropro-teome
Mass spectrometry-based proteomics has become instrumental for elucidating the molec-ular mechanisms of neurodegeneration, enabling the identification of disease-associated proteomic alterations and protein-level responses to therapeutic interventions. Building on our previous proteomic characteriza...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-14 | PXD080391 | Pride
Androgen deprivation  bioinformatics  dhed  gonadectomy  neuroprotection  neuropro-teomics  mass spectrometry  oxidative stress  visual cortex. 
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