Neuroprotection

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CHEBI ID

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Modelling Approach

Physiologically based pharmacokinetic model (1)
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Modification

4-tetrahydrothiazine-3-carboxylic acid (1)

Study type

Transcription profiling by array (66)
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Lab affiliation

Neuroimmunology Unit Institute of Experimental Neurology San Raffaele Scientific Institute Via Olgettina 60 Milan 20132, Italy (2)
Department of Experimental and Translational Ophthalmology, University Medical Center, Johannes Gutenberg University, Mainz, Germany (2)
Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Science, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, China (2)
Istituto Zooprofilattico Sperimentale delle Venezie SCS2 - Dept. of Chemistry Italy (1)
Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA (1)
Department of Biochemistry The LSUHSC Proteomic Core Facility Louisiana State University Health Sciences Center New Orleans, LA 70112 (1)
Washington University in St. Louis - School of Medicine Division of Endocrinology, Metabolism & Lipid Research (1)
University of Oslo, Department of Biosciences, Oslo, Norway (1)
Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, United States of America (1)
Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, 2610 Wilrijk, Belgium (1)
Proteomics unit at the university of Bergen (PROBE), Department of Biomedicine, University of Bergen (1)
Department of Pathology Cancer Center Stony Brook University (1)
Tanz Centre for Research in Neurodegenerative Diseases, Faculty of Medicine, University of Toronto (1)
Professor of Mass Spectrometry - Structural & Molecular Biology - UCL London UK (1)
Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA (1)
Novo Nordisk Foundation Center for Protein Research, University of Copenhagen (Denmark) (1)
Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore 575018 (1)
Experimental Ophthalmology, University Medical Center Mainz (1)
CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal; Biocant, Biotechnology Innovation Center, 3060-197 Cantanhede, Portugal (1)
Department of Environmental and Global Health, College of Public Health and Health Profession, University of Florida, Gainesville, FL (1)
Group Leader Protein Dynamics Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. Otto-Hahn-Straße 6b 44227 Dortmund, Germany (1)
Professor, Department of Chemistry, Duke University, Lab Head: Fitzgerald Lab (1)
Department of Life Sciences, University of Siena, Italy (1)
Macquarie Medical School, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia (1)
Degenerative Diseases Program, Center for Genetic Disorders and Aging Research, Sanford Burnham Prebys Medical Discovery Institute (1)
Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Athens, Greece (1)
Proteomics and Metabolomics Facility, Nebraska Center for Biotechnology (1)
MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China (1)
Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia. La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia. (1)
Department of Pharmaceutical Sciences, University at Buffalo, State University of New York (1)

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Regulation of neuronal gene and miRNA expression by the complement protein C1q associated with neuroprotection

Identification of transcriptional profiles stimulated by the complement protein C1q in rat immature neurons associated with the C1q-dependent neuroprotection observed in vitro. Use of the unbiased whole genome microarray approach to identify genes regulated by C1q. Immature neurons grown in vitro fo...

ORGANISM(S): Rattus norvegicus

2011-03-07 | E-GEOD-18860 | biostudies-arrayexpress

Transcription profiling of mouse retinal gene expression after hypoxic preconditioning identifies candidate genes for neuroprotection

Neuroprotective therapies for retinal degeneration may be used to rescue retinal cells and preserve vision. Hypoxic preconditioning stabilizes the transcription factor HIF-1Î± in the retina and strongly protects photoreceptors in an animal model of light-induced retinal degeneration. Our data sugges...

ORGANISM(S): Mus musculus

2009-01-17 | E-GEOD-14366 | biostudies-arrayexpress

Comparative transcriptome of neurons after oxygen-glucose deprivation: Potential differences in neuroprotection versus reperfusion.

Not available

S-EPMC6282217 | biostudies-literature

Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.) mediated neuroprotection in a rotenone-induced cellular model of Parkinsons disease

In the present study we carried out global and targeted metabolomics of differentiated IMR32 cells to study the neuroprotective mechanism of Yashtimadhu (Glycyrrhiza glabra L.) in rotenone induced cellular model of parkinsons disease. Our mass spectrometry data highlighted 2403 and 2934 aligned met...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2021-08-31 | MSV000088036 | MassIVE

Intergenerational Neuroprotection by an Intestinal Sphingolipid in Caenorhabditis elegans

PRJNA885375 | ENA

Potential circadian effects on translational failure for neuroprotection.

Not available

S-EPMC9466001 | biostudies-literature

A Narrative Review on Axonal Neuroprotection in Multiple Sclerosis.

Not available

S-EPMC9338208 | biostudies-literature

LC-MS/MS data of Tinospora cordifolia

Tinospora cordifolia has been used for thousands of years to treat various health conditions, including neurodegenerative diseases. The study aimed to elucidate the mechanism of action and protein targets of T. cordifolia in the context of Alzheimers disease through untargeted metabolomics and netwo...

ORGANISM(S): Tinospora Cordifolia (ncbitaxon:285590)

2024-11-04 | MSV000096283 | MassIVE

Elovanoid neuroprotection targets cell transcriptomics and proteomics to sustain synaptic integrity ater brain injury

PRJNA1435160 | ENA

GHB analogs confer neuroprotection through specific interaction with the CaMKII hub domain

Ca2+/calmodulin-dependent protein kinase II alpha (CaMK2A) is an emerging drug target incerebral ischemia for which limited therapeutic options exist. Here we show that small-molecule analogs of the brain metabolite gamma-hydroxybutyric acid (GHB) afford neuroprotection via interaction specifically ...

ORGANISM(S): Rattus norvegicus (Rat)

2021-07-22 | PXD019679 | Pride

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