Transcription profiling of mouse retinal gene expression after hypoxic preconditioning identifies candidate genes for neuroprotection

ABSTRACT: Neuroprotective therapies for retinal degeneration may be used to rescue retinal cells and preserve vision. Hypoxic preconditioning stabilizes the transcription factor HIF-1α in the retina and strongly protects photoreceptors in an animal model of light-induced retinal degeneration. Our data suggest that neuroprotection after hypoxic preconditioning of the retina is the result of the differential expression of a multitude of genes which may act in concert to protect visual cells against a toxic insult. Experiment Overall Design: In total 24 samples were analyzed on Affymetrix mouse 430.2 arrays, the samples represent different durations of regeneration (none = 0 h, 2 h, 4 h and 16 h) from hypoxic or normoxic treatments, that were tested in triplicates.

ORGANISM(S): Mus musculus

SUBMITTER: Wolfgang Raffelsberger 

PROVIDER: E-GEOD-14366 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress