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ProteomicsPeptide mass fingerprinting to investigate if histidine was incorporated as residue 136 in DHFR variants
SDS-PAGE gel bands of DHFR variants (produced using modified versions of the PURE express in vitro protein synthesis system) were analyzed via peptide mass fingerprinting (PMF). The goal was to detect which amino acids were incorporated at position 136 in DHFR.
ORGANISM(S): Escherichia coli 
2024-10-29 | PXD051338 | Pride
Lc-ms/ms Dhfr variants Pmf 
GenomicsBlocking protein quality degradation leads to structural stabilization of DHFR indel variants
Blocking protein quality degradation leads to structural stabilization of DHFR indel variants
PRJNA1289146 | ENA
OtherBlocking protein quality degradation leads to structural stabilization of DHFR indel variants
Gene variants leading to insertions or deletions of amino acid residues (indels) often have detrimental consequences for the folding of the encoded protein. Yet at some positions indels are tolerated or only result in partial unfolding. Typically unfolded proteins are targeted for protein quality co...
ORGANISM(S): Homo sapiens 
2025-12-22 | GSE302176 | GEO
OtherSystematic characterization of indel variants using a yeast-based protein folding sensor
Gene variants resulting in insertions or deletions of amino acid residues (indels) have important consequences for evolution and are often linked to disease, yet compared to missense variants the effects of indels are poorly understood and ineptly predicted. To approach this issue, we developed a se...
ORGANISM(S): synthetic construct 
2024-07-25 | GSE270811 | GEO
GenomicsSystematic characterization of indel variants using a yeast-based protein folding sensor
Systematic characterization of indel variants using a yeast-based protein folding sensor
PRJNA1128549 | ENA
Genomics
NGS data of yeast combinatorial saturation engineering in DHFR gene
PRJNA1481605 | ENA
UnknownEffects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia.
Not available
S-EPMC7472715 | biostudies-literature
Genomics
NGS data of yeast genetic variant engineering target DHFR gene
PRJNA1211711 | ENA
Genomics
Deep mutational scanning of a non-allosteric synthetic DHFR-LOV2 fusion construct
PRJNA1514100 | ENA
UnknownMaternal Haplotypes in DHFR Promoter and MTHFR Gene in Tuning Childhood Acute Lymphoblastic Leukemia Onset-Latency: Genetic/Epigenetic Mother/Child Dyad Study (GEMCDS).
Not available
S-EPMC6770441 | biostudies-literature
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