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TranscriptomicsFunction-based discovery of significant transcriptional temporal patterns in insulin-stimulated muscle cells
Background: Insulin's effect on protein synthesis (translation of transcripts) and post-translational modifications, especially those involving reversible modifications such as phosphorylation of various signaling proteins, are extensively studied. On the other hand, insulin's effect on the transcri...
ORGANISM(S): Rattus norvegicus 
2012-05-02 | E-GEOD-28997 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of yeast cells to the presence of 200 nM Rapamycin or 5 mM caffeine
To comparatively analyze the transcriptional responses of yeast cells to the presence of rapamycin or caffeine the homozygous hoΔ/hoΔ strain of S. cerevisiae BY4743 were grown in fully controlled fermenters in the presence of 200 nM rapamycin or 5 mM caffeine. Cells were cultured overnight in YPD me...
ORGANISM(S): Saccharomyces cerevisiae 
2019-03-15 | E-MTAB-7373 | biostudies-arrayexpress
TranscriptomicsARSD expression correlates with IgVH mutational status, ZAP-70 and disease progression in chronic lymphocytic leukemia
Several studies demonstrated IgVH mutation status and ZAP-70 expression as the most relevant prognostic markers in CLL, suggesting the separation of two patient subgroups: with good (MTZAP-70-) and poor prognosis (UMZAP-70+). We determined gene expression of B cells in 112 CLL patients divided into...
ORGANISM(S): Homo sapiens 
2015-01-12 | E-GEOD-28654 | biostudies-arrayexpress
TranscriptomicsCorrelating pancreatic beta cell function with their transcriptional profiles
The stage at which beta cells become functional were first determined with GSIS and Ca++ imaging. Then beta cells at key stages of maturation were purified and their gene expression alterations were determined with RNAseq and exhaustive bioinformatics analyses.
ORGANISM(S): Mus musculus 
2015-01-30 | E-MTAB-2266 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of miRNA expression profile during Mycobacterium tuberculosis infection of human primary dendritic cells
Mycobacterium tuberculosis (Mtb) is one of the most successful pathogens in human history and remains the second leading cause of death from an infectious agent worldwide. The major reason of Mtb success principally relies on its ability to perfectly adapt to the host, by establishing latent infecti...
ORGANISM(S): Homo sapiens 
2017-12-12 | E-MTAB-6083 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profile in human foreskin keratinocytes (HFKs) transduced with retroviral vectors carrying E6 and E7 genes of either HPV6 or HPV16 and with the LXSN empty vector
Cervical cancer is a leading cause of cancer-related death in women worldwide. Nearly all cases of cervical cancer are attributed to infection with human papillomavirus (HPV), mainly high-risk type HPV16 and HPV18. Two viral genes, E6 and E7, play an important role in viral life cycle, since they de...
ORGANISM(S): Homo sapiens 
2018-01-16 | E-MTAB-6360 | biostudies-arrayexpress
TranscriptomicsMicroRNA analysis in HPV-positive and HPV-negative cervical cancer cell lines
Persistent infection by high-risk human papillomaviruses (HPVs) is associated with the development of cervical cancer and a subset of anogenital and head and neck squamous cell carcinomas. Abnormal expression of cellular microRNAs (miRNAs) plays an important role in the development of cancer, includ...
ORGANISM(S): Homo sapiens 
2018-01-16 | E-MTAB-6361 | biostudies-arrayexpress
TranscriptomicsTranscriptional response in human umbilical vein endothelial cells exposed to insulin
Background: In diabetes chronic hyperinsulinemia is responsible for the instability of the atherosclerotic plaque and stimulates cellular proliferation through the activation of the MAP kinases, which, in turn regulate cellular proliferation. So far, it is not known, however, whether insulin itself ...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-21989 | biostudies-arrayexpress
TranscriptomicsIdentification of active microRNA/transcription factor feed-forward loops during human adipogenesis (miRNA)
Post-transcriptional regulation of gene expression accomplished by microRNAs (miRNAs) importantly affects the complex gene regulatory network. In particular, miRNAs are known to be involved in recurrent motifs named miRNA-mediated feed forward loops (FFLs) where a transcription factor (TF) regulates...
ORGANISM(S): Homo sapiens 
2011-12-20 | E-GEOD-29185 | biostudies-arrayexpress
TranscriptomicsIdentification of active microRNA/transcription factor feed-forward loops during human adipogenesis (mRNA)
Post-transcriptional regulation of gene expression accomplished by microRNAs (miRNAs) importantly affects the complex gene regulatory network. In particular, miRNAs are known to be involved in recurrent motifs named miRNA-mediated feed forward loops (FFLs) where a transcription factor (TF) regulates...
ORGANISM(S): Homo sapiens 
2011-12-20 | E-GEOD-29182 | biostudies-arrayexpress
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