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TranscriptomicsA host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
The innate immune system responds to unique molecular signatures that are widely conserved among microbes but that are not normally present in host cells. Compounds that stimulate innate immune pathways may be valuable in the design of novel adjuvants, vaccines, and other immunotherapeutics.The cyc...
ORGANISM(S): Mus musculus 
2009-07-21 | E-GEOD-16943 | biostudies-arrayexpress
GenomicsPseudomonas aeruginosa post-translational responses to elevated c-di-GMP levels
Pseudomonas aeruginosa post-translational responses to elevated c-di-GMP levels
PRJNA760480 | ENA
GenomicsThe Pleiotropic Effects of c-di-GMP content in Pseudomonas syringae
The Pleiotropic Effects of c-di-GMP content in Pseudomonas syringae
PRJNA494843 | ENA
Genomicsc-di-AMP Metabolism in S. aureus
New Insights into the Cyclic Di-adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic Dinucleotide for Acid Stress Resistance in Staphylococcus aureus
PRJEB14723 | ENA
GenomicsGrowth of Staphylococcus in the absence of c-di-AMP
Cyclic-di-adenosine monophosphate (c-di-AMP) is required for osmotic regulation in Staphylococcus aureus but dispensable for viability in anaerobic conditions
PRJEB22312 | ENA
TranscriptomicsPseudomonas aeruginosa post-translational responses to elevated c-di-GMP levels
C-di-GMP signaling can directly influence bacterial behavior by affecting the functionality of c-di-GMP-binding proteins. In addition, c-di-GMP can exert an indirect and more global effect on gene transcription or translation, e.g. via riboswitches or by binding to transcription factors. In this stu...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2024-09-03 | GSE183394 | GEO
GenomicsThe impact of c-di-AMP levels on gene expression in Enterococcus faecalis
The impact of c-di-AMP levels on gene expression in Enterococcus faecalis
PRJNA729656 | ENA
TranscriptomicspiRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans
Transgenerational effects likely have wide-ranging implications for human health, biological adaptation and evolution, however their mechanism and biology remain poorly understood. Here we demonstrate that a germline nuclear small RNA/chromatin pathway can maintain epi-allelic inheritance for many g...
ORGANISM(S): Caenorhabditis elegans 
2012-06-25 | E-GEOD-38813 | biostudies-arrayexpress
GenomicsIncreased c-di-AMP levels allow S. aureus to grow without LTA
Increased c-di-AMP levels allow Staphylococcus aureus growth in the absence of lipoteichoic acid
PRJEB2431 | ENA
TranscriptomicsThe Pleiotropic Effects of c-di-GMP content in Pseudomonas syringae
Although the ubiquitous bacterial secondary messenger cyclic diguanylate (c-di-GMP) plays important roles in various cellular functions including the formation of biofilm in a wide range of bacteria, its function in model plant pathogen Pseudomonas syringae is largely elusive. In order to test this ...
ORGANISM(S): Pseudomonas syringae pv. syringae B728a 
2019-03-31 | GSE120889 | GEO
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