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Unknownm-Terphenylamines, Acting as Selective COX-1 Inhibitors, Block Microglia Inflammatory Response and Exert Neuroprotective Activity.
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S-EPMC10384011 | biostudies-literature
ProteomicsMeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation
Rett syndrome is a human intellectual disability disorder that is associated with mutations in the X-linked MECP2 gene. Theepigenetic reader MeCP2 binds to methylated cytosines on the DNA and regulates chromatin organization. We have shownpreviously that MECP2 Rett syndrome missense mutations are im...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-15 | PXD033696 | Pride
Lc-ms/ms Brain Mouse 
TranscriptomicsTranscription profiling of Salmonella enteritidis to determine the effect of the absence of GGDEF proteins on the transcriptional pattern
Effect of the absence of GGDEF proteins on the transcriptional pattern in Salmonella.
ORGANISM(S): Salmonella enteritidis 
2009-12-11 | E-MEXP-2066 | biostudies-arrayexpress
MetabolomicsgeoRge: A Computational Tool To Detect the Presence of Stable Isotope Labeling in LC/MS-Based Untargeted Metabolomics
Studying the flow of chemical moieties through the complex set of metabolic reactions that happen in the cell is essential to understanding the alterations in homeostasis that occur in disease. Recently, LC/MS-based untargeted metabolomics and isotopically labeled metabolites have been used to facil...
2015-09-15 | MTBLS213 | MetaboLights
ProteomicsStructural and functional differentiation of the light-harvesting protein Lhcb4 during land plant diversification
About 475 million years ago plants originated from an ancestral green alga and evolved first as non-vascular and later as vascular plants, becoming the primary producers of biomass on lands. During that time, the light harvesting complex II (LHCII), responsible for sunlight absorption and excitation...
ORGANISM(S): Pisum sativum (Garden pea) 
2019-03-25 | PXD011213 | Pride
Proteomics Light acclimation Swath Psii Land plants evolution Label-free Lhcii Light harvesting 
Proteomics,MultiomicsElectrophilic stress induced by itaconate and its derivatives regulates ATF3-IKBZ inflammatory axis independently of Nrf2 induction
Metabolic regulation recently emerged as a novel powerful principle guiding immune responses. The natural metabolite itaconate and its membrane permeable derivative dimethyl itaconate (DI) were recently shown to selectively inhibit a subset of cytokines during macrophage activation, yet the precise ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-02-25 | MSV000082101 | MassIVE
MetabolomicsUntargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

INTRODUCTION: Interesting data about the family Asteraceae as a new source of Leishmania major dihydroorotate dehydrogenase (LmDHODH) inhibitors are presented. This key macromolecular target for parasites causing neglected diseases catalyzes the fourth reaction of the de novo pyr...

2019-10-14 | MTBLS722 | MetaboLights
TranscriptomicsAnalysis of miRNA profiles in CD4+ T-lymphocytes following exposure to HIV-1
Assessment of the extent to which the altered profiles of miRNA expression influence viral replication and latency, as well as the efficiency of host defenses, may be useful for understanding the basis of the HIV-1-related alterations in cellular physiology and immunologic control. To this end, thre...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-GEOD-33514 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Salmonella enteritidisto determine the effect of the absence of GGDEF proteins on the transcriptional pattern
Effect of the absence of GGDEF proteins on the transcriptional pattern in Salmonella.
ORGANISM(S): Salmonella enteritidis 
2009-12-11 | E-MEXP-2067 | biostudies-arrayexpress
TranscriptomicsThe Mitochondrial Calcium Uniporter controls skeletal muscle mass in vivo
Muscle atrophy contributes to the poor prognosis of many physiopathological conditions, but pharmacological therapies are still limited. Muscle activity leads to major swings in mitochondrial [Ca2+] which control aerobic metabolism, cell death and survival pathways. We have investigated in vivo the ...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-60931 | biostudies-arrayexpress
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