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ProteomicsCharacterization of progressive denaturation and unfolding intermediates of proteins by fast cross-linking using di-ortho-phthalaldehyde
Chemical cross-linking of proteins coupled with mass spectrometry (CXMS) is widely used in protein structural analysis. In this study we develop a new class of non-hydrolyzable amine-selective di-ortho-phthalaldehyde (DOPA) cross-linkers, one of which is DOPA2. Cross-linking of proteins with DOPA2 i...
ORGANISM(S): Staphylococcus Aureus Bos Taurus 
2021-12-20 | PXD030552 |
UnknownPoly[(μ(2)-3,6-di-4-pyridyl-1,2,4,5-tetra-zine)(μ(2)-thio-cyanato)copper(I)].
Not available
S-EPMC2979958 | biostudies-literature
TranscriptomicsPTEN loss deM-oM-,M-^Anes a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) represents a heterogeneous diagnostic category with distinct molecular subtypes that can be deM-oM-,M-^Aned by gene expression proM-oM-,M-^Aling. However, even within these deM-oM-,M-^Aned subtypes, heterogeneity prevails. To further elucidate the pathogenesis o...
ORGANISM(S): Homo sapiens 
2013-07-09 | E-GEOD-45495 | biostudies-arrayexpress
TranscriptomicsmicroRNA Expression in HCC Tissues and Cells
Cell Lines, Cultures and HCC Tumor Tissues.
Malignant and non-malignant hepatocyte cell lines were obtained from the American Type Culture Collection (Manassas, VA) and cultured as recommended by the supplier. Total RNA from three paires of normal human liver tissue and from hepatocellular car...
ORGANISM(S): Homo sapiens 
2011-08-03 | E-MEXP-1125 | biostudies-arrayexpress
TranscriptomicsUbe3a-ATS characterization with strand-speicific microarray
This strand-specific array is performed to characterize expression features of Ube3a-ATS, including its imprinting status, its exon-intron structure, its transcriptional initiation and termination site as well as its polyadenylation status. The array contains reverse-complementary probes detecting t...
ORGANISM(S): Mus musculus 
2012-05-02 | E-GEOD-29254 | biostudies-arrayexpress
TranscriptomicsLncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [ChIRP-seq]
While thousands of long non-coding RNAs (lncRNAs) are expressed in higher eukaryotes, the potential regulatory roles of lncRNAs in regulated gene transcription programs remain rather poorly understood. Here, we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 and PC...
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-47804 | biostudies-arrayexpress
TranscriptomicsConvergent Sense/Antisense Transcription At Intragenic Super-Enhancers Targets AID-initiated Genomic Instability
Activation-induced cytidine deaminase (AID) initiates both somatic hypermutation (SHM) for antibody affinity maturation and DNA breakage for antibody class switch recombination (CSR) via transcription-dependent cytidine deamination of single stranded DNA targets. While largely specific for immunglob...
ORGANISM(S): Homo sapiens 
2014-12-04 | E-GEOD-62296 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptome analysis of the pH regulator pacC in Colletotrichum gloeosporioides
Colletotrichum gloeosporioides, a widely distributed economically important agent in postharvest fruit disease thrives by massive secretion of ammonia to alkalize its environment and activate its pathogenicity genes. We sequenced the C. gloeosporioides transcriptomes of WT and a M-bM-^HM-^FpacC muta...
ORGANISM(S): Colletotrichum gloeosporioides 
2013-11-21 | E-GEOD-41844 | biostudies-arrayexpress
TranscriptomicsDifferential expression in response to water deficit in diploid leaves of sweet orange scion grafted alternatively on a diploid or auto-tetraploid Rangpur lime rootstock: data concerning the scion grafted onto diploid rootstock.
Whole-genome duplication, or polyploidy, is common in many plant species and often leads to better adaptation to adverse environmental condition. However, little is known about the physiological and molecular determinants underlying adaptation. We examined the drought tolerance in diploid (2x) and a...
ORGANISM(S): Citrus limonia 
2012-10-05 | E-GEOD-41309 | biostudies-arrayexpress
TranscriptomicsDifferential expression in response to water deficit in diploid leaves of sweet orange scion grafted alternatively on a diploid or auto-tetraploid Rangpur lime rootstock: data concerning the scion grafted onto tetraploid rootstock
Whole-genome duplication, or polyploidy, is common in many plant species and often leads to better adaptation to adverse environmental condition. However, little is known about the physiological and molecular determinants underlying adaptation. We examined the drought tolerance in diploid (2x) and a...
ORGANISM(S): Citrus limonia 
2012-10-05 | E-GEOD-41310 | biostudies-arrayexpress
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