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MetabolomicsLsr2, a novel cyclic di-GMP receptor, regulate the synthesis of keto-mycolic acid and control biofilm formation in mycobacteria

Cyclic di-GMP (c-di-GMP) is a well-known second messenger that plays a key role in many physiological processes in bacteria. The synthesis of lipids is essential for bacterial biofilm formation. However, whether c-di-GMP signaling modulates the synthesis of lipid and further regulates biofilm for...

2023-12-12 | MTBLS7053 | MetaboLights
ProteomicsCharacterization of progressive denaturation and unfolding intermediates of proteins by fast cross-linking using di-ortho-phthalaldehyde
Chemical cross-linking of proteins coupled with mass spectrometry (CXMS) is widely used in protein structural analysis. In this study we develop a new class of non-hydrolyzable amine-selective di-ortho-phthalaldehyde (DOPA) cross-linkers, one of which is DOPA2. Cross-linking of proteins with DOPA2 i...
ORGANISM(S): Staphylococcus Aureus Bos Taurus 
2021-12-20 | PXD030552 |
UnknownIdentification and Characterization of c-di-GMP Metabolic Enzymes of Leptospira interrogans and c-di-GMP Fluctuations After Thermal Shift and Infection.
Not available
S-EPMC5932348 | biostudies-literature
ProteomicsProteome-wide identification of Lysine Methylation on non-histone of tomato (Solanum Lycopersicum) during ripening
Post-translational modification of proteins through methylation plays important regulatory role in biological processes. Lysine methylation on histone proteins is known to play important role in chromatin structure and function. However, non-histone protein substrates of this modification remain lar...
ORGANISM(S): Solanum lycopersicum 
2023-03-11 | PXD023985 | Pride
Lysine  methylation  post-translational modification  tomato 
UnknownChloro-cobalt complexes with pyridyl-ethyl-derived di-aza-cyclo-alkanes.
Not available
S-EPMC8900507 | biostudies-literature
Unknown2,2'-(Butane-1,4-di-yl)diisoquinolinium tetra-chloridozincate(II).
Not available
S-EPMC2959863 | biostudies-literature
UnknownSynthesis and degradation of the cyclic dinucleotide messenger c-di-AMP in the hyperthermophilic archaeon Pyrococcus yayanosii.
Not available
S-EPMC10680344 | biostudies-literature
TranscriptomicsGlobal analyses of endonucleolytic cleavage in mammals reveal expanded repertoires of cleavage-inducing small RNAs and their targets
In mammals, small RNAs are important players in post-transcriptional gene regulation. While their roles in mRNA destabilization and translational repression are well appreciated, their involvement in endonucleolytic cleavage of target RNAs is poorly understood. Very few microRNAs are known to guide ...
ORGANISM(S): Homo sapiens 
2016-03-16 | E-GEOD-68253 | biostudies-arrayexpress
MetabolomicsMetabolite signatures of diverse Camellia sinensis tea populations
Tea plants (Camellia sinensis) present an excellent system to study evolution and diversification of specialized metabolites due to their abundance in classes, numbers and contents. A large number of tea cultivars have been cultivated throughout the world not only because of their adaption to differ...
2020-10-05 | MTBLS1405 | MetaboLights
UnknownCyclic di-GMP as an antitoxin regulates bacterial genome stability and antibiotic persistence in biofilms.
Not available
S-EPMC11452175 | biostudies-literature
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