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TranscriptomicsMolecular signatures of heterogeneous stem cell populations are resolved by linking single cell functional assays to single cell gene expression
The discovery of significant heterogeneity in the self-renewal durability of adult haematopoietic stem cells (HSCs) has challenged our understanding of the molecules involved in population maintenance throughout life. Gene expression studies in bulk populations are difficult to interpret since mult...
ORGANISM(S): Mus musculus 
2015-05-26 | E-GEOD-61533 | biostudies-arrayexpress
TranscriptomicsThe transcriptional landscape of mouse blood stem/progenitor cell transitions at single cell resolution
Current gene-expression databases for the haematopoietic system provide information on gene expression profiles present in bulk populations. Although informative, these studies lack the resolution that can be gained at a single-cell level. In particular, population-average data assumes homogeneity w...
ORGANISM(S): Mus musculus 
2016-07-04 | E-GEOD-81682 | biostudies-arrayexpress
TranscriptomicsGenome-wide ChIP-seq binding profiles and linked gene expression arrays
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-64069 | biostudies-arrayexpress
TranscriptomicsGenome-wide ChIP-seq binding profiles and linked gene expression arrays [array]
Pu.1-mutated murine AML cell line X18.1.1 transfected with inducible Pu.1 (PuER) or empty vector (EV) and clonal lines selected. Cells were induced with OHT for 2 hours prior to collection for ChIPSeq and expression arrays. Examination of RNA expression profile by array
ORGANISM(S): Mus musculus 
2015-12-08 | E-GEOD-64068 | biostudies-arrayexpress
GenomicsAP2gamma ChIPseq
As a part of a modelling experiment for transcriptional control of mouse primordial germ cell specification, the transcription factor AP2gamma was stably expressed in the mouse p19 embryonal carcinoma cell line and its genome wide binding sites were defined using ChIPseq.
ORGANISM(S): Mus musculus 
2013-07-17 | E-MTAB-1600 | biostudies-arrayexpress
GenomicsBLIMP1 ChIPseq
As a part of a modelling experiment for transcriptional control of mouse primordial germ cell specification, the transcription factor BLIMP1 was transiently expressed in the mouse p19 embryonal carcinoma cell line and its genome wide binding sites were defined using ChIPseq.
ORGANISM(S): Mus musculus 
2013-07-17 | E-MTAB-1599 | biostudies-arrayexpress
TranscriptomicsMouse embryonic RNA-seq
The study was aimed at interrogating the early stages of blood cell development within the embryo. Blood develops from mesoderm, which is specified at gastrulation. We therefore sorted cells from mouse embryos between E6.5 and E7.75 to capture gastrulation and the emergence of mesoderm, followed b...
ORGANISM(S): Mus Musculus 
2016-07-08 | E-MTAB-4079 | biostudies-arrayexpress
TranscriptomicsBRACHYURY knockdown in differentiating hESCs
Transcriptional profiling of H9 hESCs (wild type and BRACHYURY shRNA knockdown) differentiated for 36h or 72h in chemically-defined culture media supplemented with FGF2, LY294002 and either BMP4 or ActivinA.
ORGANISM(S): Homo sapiens 
2015-05-19 | E-MTAB-2912 | biostudies-arrayexpress
GenomicsThe Growth factor independence 1 (GFI1) 36N variant predisposes to Acute Myeloid Leukemia (AML) by inducing epigenetic changes at the Hoxa9 locus
GFI136N is a coding Single Nucleotide Polymorphism (SNP) in the gene GFI1 that increases the risk for Acute myeloid leukemia (AML) by 60%. It is present in 3-5% of Caucasians and has a prevalence of 12% among AML patients. We generated knockin mice expressing either the human GFI136N variant or the ...
ORGANISM(S): Mus musculus 
2012-12-04 | E-GEOD-31657 | biostudies-arrayexpress
GenomicsSingle Cell Expression Profiling Resolves the Transcriptional Programs of Early Mesoderm Diversification
We analyzed 1,205 cells from the epiblast and nascent mesoderm of gastrulating mouse embryos by single cell RNA-seq, representing the first transcriptome-wide in vivo view of mammalian gastrulation. Based on the distribution of key marker genes and their spatiotemporal expression patterns within the...
ORGANISM(S): Mus musculus 
2016-07-07 | E-GEOD-74994 | biostudies-arrayexpress
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