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TranscriptomicsDefective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia.
Transcriptome profile of highly purified multipotential (P), erythroid (E), and myeloid (M) bone marrow progenitors from three RPS19 mutated Diamond-Blackfan anemia and six control human subjects. Two group comparison of sex and age matched subjects. Bone marrow progenitors, gene expression profilin...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-41599 | biostudies-arrayexpress
TranscriptomicsRibosomal Protein Gene Deletions in Diamond Blackfan Anemia
Diamond Blackfan anemia is a congenital bone marrow failure syndrome characterized by hypoproliferative anemia, often with associated physical abnormalities. Perturbations of the ribosome appear critically important to the development of DBA, as alterations in 9 different ribosomal protein genes ha...
ORGANISM(S): Homo sapiens 
2012-01-15 | E-GEOD-31575 | biostudies-arrayexpress
TranscriptomicsRibosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts
Diamond Blackfan Anemia (DBA) is associated with developmental defects and profound anemia. Mutations in genes encoding a ribosomal protein of the small (e.g. Rps19) or large (e.g. Rpl11) ribosomal subunit are found in over half of these patients. The mutations cause ribosomal haploinsufficiency, ...
ORGANISM(S): Mus musculus 
2011-11-14 | E-GEOD-22903 | biostudies-arrayexpress
TranscriptomicsEffect of c-Myb knockdown on global gene expression
Effect of c-Myb knockdown in K562 on global gene expression after knockdown using siRNA oligo si323 or si2992.
ORGANISM(S): Homo sapiens 
2012-01-01 | E-MTAB-807 | biostudies-arrayexpress
TranscriptomicsDEN-induced HCC in c-Met knockout mice
HGF has been reported to have both positive and negative effects on carcinogenesis. Here we show that the loss of c-Met signaling in hepatocytes enhanced rather than suppressed the early stages of chemical hepatocarcinogenesis. c-Met conditional knockout mice (c-metfl/fl, AlbCre+/-; MetLivKO) treate...
ORGANISM(S): Mus musculus 
2008-08-09 | E-GEOD-8747 | biostudies-arrayexpress
Transcriptomics5q- Myelodysplastic Syndrome Masquerading as Diamond Blackfan Anemia
Diamond Blackfan anemia is a congenital bone marrow failure syndrome characterized by hypoproliferative anemia, often with associated physical abnormalities. Perturbations of the ribosome appear critically important to the development of DBA, as alterations in 9 different ribosomal protein genes ha...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-GEOD-42570 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. elegans IG274 wt frIs7 and IG339 nipi-1(fr1) frIs7 after infection with Dreshmeria coniosporia
1.Sample Growth Conditions protocols
Eggs from IG274 wt; frIs7 and IG339 nipi-1(fr1); frIs7 worms cultivated at 25°C were allowed to hatch in the absence of food at 25°C for 16 hours. Synchronised larvae were transferred to NGM agar plates lawned with OP50 and cultivated at 25°C for 48 hou...
ORGANISM(S): Caenorhabditis elegans 
2009-10-29 | E-MEXP-1364 | biostudies-arrayexpress
GenomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-Seq
Recruitment of the RNA Polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA binding transcription factors is well recognized as a key regulatory step in gene expression. We describe here evidence that promoter-proximal pausing is a general feature of transcription ...
ORGANISM(S): Mus musculus 
2010-04-02 | E-GEOD-20530 | biostudies-arrayexpress
TranscriptomicsLow input Hi-C datasets for a diffuse large B-cell lymphoma sample, healthy control human B-cells and mouse embryonic stem cells
In this experiment, we've examined chromatin conformation of OG2 (B6; CBA-Tg(Pou5f1-EGFP)2Mnn/J; stock number 004654) mouse stem cells cultured as described in (Shi et al., 2008), using different amounts of starting cells. We performed a modified in situ Hi-C protocol for 6 samples digested with Mbo...
ORGANISM(S): Mus musculus 
2018-11-30 | E-MTAB-5875 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and C/EBPbeta deficient mice during a partial hepatectomy time series to identify transcriptional targets of C/EBPbeta
The aim of this experiment was to use microarray analysis to compare the response of wild type (WT) and C/EBPbeta deficient (KO) mice during a partial hepatectomy time course in hopes of identifying transcriptional targets of C/EBPbeta. In addition, the WT time course alone was examined to analyze m...
ORGANISM(S): Mus musculus 
2006-10-03 | E-CBIL-16 | biostudies-arrayexpress
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