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MetabolomicsIntestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets
Diarrheal disease is a common health problem with complex causality. Although diarrhea is accompanied by disturbances in microbial diversity, how gut microbes are involved in the occurrence of diarrhea remains largely unknown. Here, using a pig model of post-weaning stress-induced diarrhea, we aim t...
2023-01-09 | MTBLS4040 | MetaboLights
MetabolomicsLacto-N-tetraose mediates indole-3-lactic acid production by Bifidobacterium longum subsp. infantis to alleviate enterotoxigenic Escherichia coli-induced diarrhea in infants

Enterotoxigenic Escherichia coli (ETEC) is a leading cause of infectious diarrhea and poses a threat to infant health. Current treatments for ETEC infection primarily rely on antibiotics，which face limitations due to resistance and side effect. In this cross-sectional study, we analyzed fecal met...

2025-08-24 | MTBLS12886 | MetaboLights
MetabolomicsPorcine epidemic diarrhea virus manipulates IMPDH-dependent nucleotide biosynthesis to facilitate replication

Porcine epidemic diarrhea virus (PEDV) causes acute intestinal disease in pigs and remains a major threat to the global swine industry due to its high morbidity and mortality in neonatal piglets. To investigate host metabolic alterations upon PEDV infection, we performed untargeted metabolomic pr...

2025-10-17 | MTBLS13153 | MetaboLights
MetabolomicsUntargeted metabolomics reveals bovine viral diarrhea virus infection reprogram host nucleotide and amino acid metabolism in MDBK Cells

Bovine viral diarrhea virus (BVDV) is a highly adapted intracellular parasite that depends entirely on the host cell's metabolic resources and energy for the synthesis of viral components. However, the mechanisms by which BVDV remodels host lipid metabolism remain unclear. In this study, we explo...

2025-10-12 | MTBLS13126 | MetaboLights
MetabolomicsIntegrated metagenomic binning and metabolomic profiling reveal a microbial-bile acid feedback loop in neonatal calf diarrhea

A metagenomic binning analysis was performed on fecal samples from 50 healthy calves and 50 diarrheic calves to comprehensively investigate the association between microbial dysbiosis and calf diarrhea. By integrating shotgun metagenomics, untargeted metabolomics, targeted bile acid metabolomics,...

2026-10-23 | MTBLS13800 | MetaboLights
MetabolomicsXiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea via TGR5-FAK-RhoA/Rock signaling revealed by integrated metabolomics and proteomics

Irinotecan (CPT-11) is widely used for colorectal cancer treatment, with delayed-onset diarrhea as its primary side effect. Xiao-Chai-Hu-Tang (XCHT) has been clinically observed to alleviate diarrhea, but its mechanisms remain unclear. This study aimed to explore the underlying regulatory mechani...

2025-09-03 | MTBLS12931 | MetaboLights
MetabolomicsA study of the relationship between post-cholecystectomy diarrhea and intestinal microecology

Background and Aims:Cholecystectomy is the preferred surgical procedure for treating gallstones,but the incidence of postcholecystectomy diarrhea (PCD) varies considerably,and its association with the intestinal microbiota remains unclear.This study aims to investigate the effects of cholecystect...

2025-12-19 | MTBLS13528 | MetaboLights
MetabolomicsEngineered Bacillus subtilis WB600/ZD reduces post-weaning diarrhea in piglets by modulating gut microbiota and aryl hydrocarbon receptor (AHR) signaling

Post-weaning diarrhea (PWD) causes significant economic losses to the pig farming industry. Our previous study demonstrated that the engineered Bacillus subtilis WB600/ZD (an engineered Bacillus subtilis strain expressing the antimicrobial defensin peptide from Zophobas atratus), alleviates intes...

2025-08-15 | MTBLS12862 | MetaboLights
MetabolomicsChanges in the Abundance of the Fecal Microbiota are Implicated in the Pathogenesis of Diarrhea in Yak Calves

The yak, an economically vital species on the Qinghai-Tibet Plateau, faces a significant challenge with diarrhea during the calf stage. However, studies about diarrhea of yak calves were few. Due to the close link between diarrhea and intestinal microbiota. Therefore, this study analyzed the feca...

2026-06-03 | MTBLS13964 | MetaboLights
TranscriptomicsDifferentially-expressed miRNAs in MDBK cells infected with bovine viral diarrhea virus compared to MDBK cells
Non-canonical microRNAs (miRNAs) are a class of short endogenous RNA molecules with the ability to control development, autophagy, apoptosis and the stress response in eukaryotes by pairing with partially complementary sites in the 3' untranslated regions (UTRs) of targeted genes. Recent studies hav...
ORGANISM(S): Bos taurus 
2014-12-16 | E-GEOD-61251 | biostudies-arrayexpress
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