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TranscriptomicsComorbidity-Specific Molecular Programs of Early Diastolic Dysfunction Identify Glucocorticoid Receptor Activation as a Causal Driver in Obesity
Early diastolic dysfunction precedes the development of HFpEF, but the molecular events that initiate this process remain poorly defined. HFpEF arises in the setting of systemic comorbidities such as obesity, hypertension, hyperglycemia, and sleep apnea, which often coexist and make it difficult to ...
ORGANISM(S): Mus musculus 
2026-07-03 | E-MTAB-16848 | biostudies-arrayexpress
GenomicsPericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction
Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction
PRJNA1057043 | ENA
GenomicsMitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF
Mitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF
PRJNA1301320 | ENA
GenomicsDerepression of Gene Expression Underlies HDAC Inhibitor-Mediated Reversal of Diastolic Dysfunction [scRNA-seq]
Derepression of Gene Expression Underlies HDAC Inhibitor-Mediated Reversal of Diastolic Dysfunction [scRNA-seq]
PRJNA1524520 | ENA
GenomicsDerepression of Gene Expression Underlies HDAC Inhibitor-Mediated Reversal of Diastolic Dysfunction [RNA-seq]
Derepression of Gene Expression Underlies HDAC Inhibitor-Mediated Reversal of Diastolic Dysfunction [RNA-seq]
PRJNA1524521 | ENA
GenomicsDerepression of Gene Expression Underlies HDAC Inhibitor-Mediated Reversal of Diastolic Dysfunction [ATAC-seq]
Derepression of Gene Expression Underlies HDAC Inhibitor-Mediated Reversal of Diastolic Dysfunction [ATAC-seq]
PRJNA1524523 | ENA
GenomicsSorbs2 Deficiency Causes Diastolic Dysfunction Through Dysregulation of Cytoskeletal Networks and Calcium Handling
Sorbs2 Deficiency Causes Diastolic Dysfunction Through Dysregulation of Cytoskeletal Networks and Calcium Handling
PRJNA1312112 | ENA
GenomicsSex Differences in Heart Mitochondria: Relationship to Diastolic Dysfunction
Sex Differences in Heart Mitochondria: Relationship to Diastolic Dysfunction
PRJNA799318 | ENA
TranscriptomicsCLINICAL SYMPTOMS OF RIGHT VENTRICULAR FAILURE IN EXPERIMENTAL CHRONIC PRESSURE LOAD ARE ASSOCIATED WITH PROGRESSIVE DIASTOLIC DYSFUNCTION
Right ventricular failure (RVF) due to pressure load is a major cause of death in congenital heart diseases and pulmonary hypertension. The mechanisms of RVF are yet unknown. Research is hampered by the lack of a good RVF model. Our aim was to study the pathophysiology of RVF in a rat model of chron...
ORGANISM(S): Rattus norvegicus 
2014-12-08 | E-GEOD-46863 | biostudies-arrayexpress
GenomicsFibroblast-restricted inflammasome activation promotes atrial fibrillation and heart failure with diastolic dysfunction
Fibroblast-restricted inflammasome activation promotes atrial fibrillation and heart failure with diastolic dysfunction
PRJNA902802 | ENA
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