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TranscriptomicsThe small RNA repertoire of Dictyostelium discoideum
Small RNAs play crucial roles in regulation of gene expression in many eukaryotes. Here, we report the cloning and characterization of 18-26 nt RNAs in the social amoeba Dictyostelium discoideum. This survey uncovered developmentally regulated microRNA candidates whose biogenesis, at least in one ca...
ORGANISM(S): Dictyostelium discoideum 
2007-10-16 | E-GEOD-8755 | biostudies-arrayexpress
TranscriptomicsCHD chromatin remodelers regulate separate gene sets and distinct stages of Dictyostelium development
We utilized RNA-seq to profile expression levels in wild type AX2 cells and three mutants for the CHD family of ATP-dependent chromatin remodellers in Dictyostelium discoideum. Total RNA was polyA enriched and sequenced at two stages of development: in the growth stage (0H) and in 5H cAMP pulsed cel...
ORGANISM(S): Dictyostelium discoideum 
2014-01-03 | E-GEOD-47222 | biostudies-arrayexpress
TranscriptomicsAllorecognition, via TgrB1 and TgrC1, mediates the transition from unicellularity to multicellularity in the social amoebae Dictyostelium discoideum
The social amoeba Dictyostelium discoideum integrates into a multicellular organism when individual starving cells aggregate and form a mound. The cells then integrate into defined tissues and develop into a fruiting body that consists of a stalk and spores. Aggregation is initially orchestrated by ...
ORGANISM(S): Dictyostelium discoideum 
2016-04-13 | E-GEOD-68063 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Dictyostelium discoideum wild type and dupA null after infection with Legionella pneumophila
The social amoeba Dictyostelium discoideum is vulnerable to infection by the pathogen that causes Legionnaire's Disease, Legionella pneumophila. Dictystelium cells lacking the dual-specificity phospahatase DupA are at least partially resistant to infection, and strikingly the expression profile of u...
ORGANISM(S): Dictyostelium discoideum 
2009-09-24 | E-TABM-509 | biostudies-arrayexpress
TranscriptomicsRNA-Seq data of terminal differentiated cells in Dictyostelium discoideum
The intent of the experiment was to gather transcriptomic data from terminally differentiated cell types --spore, stalk, and cup cells-- in a simple multicellular model system, Dictyostelium discoideum, in order to characterize the cell-type specific gene expression patterns. Specifically, we dissoc...
ORGANISM(S): Dictyostelium discoideum 
2019-01-31 | E-MTAB-7215 | biostudies-arrayexpress
TranscriptomicsDifferential expression of Dictyostelium discoideum AX2 upon infection with wt L. pneumophila JR32 vs. uninfected 1h p.i. (timecourse experiment)
Differential gene expression of Dictyostelium discoideum after infection with Legionella pneumophila in comparison to uninfected cells was investigated using DNA microarrays. Investigation of a 48 h time course of infection revealed several clusters of co-regulated genes, an enrichment of preferenti...
ORGANISM(S): Dictyostelium discoideum 
2013-09-25 | E-GEOD-50963 | biostudies-arrayexpress
TranscriptomicsDifferential expression of Dictyostelium discoideum AX2 upon infection with wt L. pneumophila JR32 vs. uninfected 24h p.i. (timecourse experiment)
Differential gene expression of Dictyostelium discoideum after infection with Legionella pneumophila in comparison to uninfected cells was investigated using DNA microarrays. Investigation of a 48 h time course of infection revealed several clusters of co-regulated genes, an enrichment of preferenti...
ORGANISM(S): Dictyostelium discoideum 
2013-09-25 | E-GEOD-50964 | biostudies-arrayexpress
TranscriptomicsDifferential expression of Dictyostelium discoideum AX2 upon infection with wt L. pneumophila JR32 vs. uninfected 48h p.i. (timecourse experiment)
Differential gene expression of Dictyostelium discoideum after infection with Legionella pneumophila in comparison to uninfected cells was investigated using DNA microarrays. Investigation of a 48 h time course of infection revealed several clusters of co-regulated genes, an enrichment of preferenti...
ORGANISM(S): Dictyostelium discoideum 
2013-09-25 | E-GEOD-50965 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Dictyostelium discoideum in response to infection with Pseudomonas aeruginosa PA01 and PA14 strains which differ in virulence
Pseudomonas aeruginosa is an opportunistic human pathogen, infecting immuno-compromised patients and causing persistent respiratory infections in people affected from cystic fibrosis. Pseudomonas strain Pseudomonas aeruginosa PA14 shows higher virulence than Pseudomonas aeruginosa PAO1 in a wide ran...
ORGANISM(S): Dictyostelium discoideum 
2008-07-09 | E-TABM-464 | biostudies-arrayexpress
TranscriptomicsDifferential expression of Dictyostelium discoideum AX2 upon infection with wt L. pneumophila JR32 vs. the L. pneumophila delta DotA mutant 24h p.i.
Differential gene expression of Dictyostelium discoideum after infection with Legionella pneumophila was investigated using DNA microarrays. A detailed analysis of the 24 h time point post infection was performed in comparison to three controls, uninfected cells and co-incubation with Legionella hac...
ORGANISM(S): Dictyostelium discoideum 
2013-09-07 | E-GEOD-50536 | biostudies-arrayexpress
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