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TranscriptomicsRNA-seq of small intestinal macrophages, neutrophils, CD103-CD11b+cDC and cryptopatch and ILF associated mononuclear phagocytes (CIA-MPh)
Cryptopatches (CP) and isolated lymphoid follicles (ILF) are evolutionary ancient lymphoid structures found in the intestines of all vertebrates. These structures are demarcated by a poorly characterised subset of mononuclear phagocytes (MPh), called CP/ILF-associated (CIA)-MPh. CIA-MPh expressed v...
ORGANISM(S): Mus musculus 
2020-11-24 | E-MTAB-9505 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of small intestinal dendritic cells from C57BL/6, RORgt-/- and RORgt-Cre x Ltb-flox mice
Cryptopatches (CP) and isolated lymphoid follicles (ILF) are evolutionary ancient lymphoid structures found in the intestines of all vertebrates. These structures are demarcated by a poorly characterised subset of mononuclear phagocytes (MPh), called CP/ILF-associated (CIA)-MPh. We could demonstrat...
ORGANISM(S): Mus musculus 
2020-11-24 | E-MTAB-9522 | biostudies-arrayexpress
TranscriptomicsMicroarray profiling of polyploid macrophage progeny
To explore how bacterial lipoproteins (i.e. TLR2 ligands) increased macrophage ploidy via mitotic defects, we performed global analysis of cell cycle gene expression changes induced by bacterial lipoproteins. FSL-1 (Pam2CGDPKHPKSF) is a synthetic lipoprotein that represents the N-terminal part of th...
ORGANISM(S): Mus musculus 
2016-10-27 | E-MTAB-5085 | biostudies-arrayexpress
TranscriptomicsRNA Seq of colonic Lgr5+ epithelial stem cells in Il22+/+ and Il22-/- mice during homeostasis and 24h after irradiation with 8 Gy
To investigate the influence of Interleukin-22 (IL-22) on colonic intestinal stem cells, we assessed gene expression in these cells during homeostasis and after induction of DNA damage. IL-22 is a lymphocyte-derived cytokine that targets exclusively non-hematopoietic cells. The receptor is expressed...
ORGANISM(S): Mus musculus 
2019-01-01 | E-MTAB-6723 | biostudies-arrayexpress
TranscriptomicsThe transcription factor GATA3 controls cell fate and maintenance of type 2 innate lymphoid cells
The microarray was designed in order to detect transcriptional similarities/differences between innate immune cells (ILCs) in the lamina propria (N;L;R) and a putative precursor cell type detected in the bone marrow (P) of untreated mice in steady-state.
ORGANISM(S): Mus musculus 
2012-10-18 | E-MEXP-3743 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of steady-state and LPS stimulated splenic classical dendritic cells from wild type, germ-free and IFNAR knockout mice
The transcriptome of splenic classical dendritic cells (cDCs) (CD3- CD19- CD45+ MHC-II+ CD11c+) was compared in Wild Type (WT) mice, Germ Free (GF) mice and mice deficient for the Ifnar1 gene (IFNAR). Cells were isolated and sorted by flow cytometry to high purity. The cells were stimulated ex vivo ...
ORGANISM(S): Mus musculus 
2018-06-30 | E-MTAB-5190 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of primary isolated unstimulated murine splenic DC1 and DC2 from specific pathogen free (SPF), Germ free (GF) and Interferon alpha/beta receptor 1 (Ifnar) knock out mice
The transcriptomes of primary isolated unstimulated murine splenic cDC1 and cDC2 from specific pathogen free (SPF) were compared to cDC1 and cDC2 from Germ Free (GF) and Interferon alpha/beta receptor 1 (Ifnar) knock out mice. Total RNA was prepared from sort-purified cDC1 and cDC2 (for each sample ...
ORGANISM(S): Mus musculus 
2020-03-30 | E-MTAB-8883 | biostudies-arrayexpress
GenomicsChIP-Seq (H3K4me3, H3K27me3) of steady-state splenic classical dendritic cells from wild type, germ-free and IFNAR knockout mice
The epigenetic state of splenic cDCs from Wild Type (WT) mice, Germ Free (GF) and mice deficient for the Ifnar1 gene (IFNAR) was characterized by analyzing the occupancy of a major activating histone mark (H3K4me3) and a major repressive histone mark (H3K27me3). Splenic cDCs (CD3- CD19- CD45+ MHC-II...
ORGANISM(S): Mus musculus 
2018-06-30 | E-MTAB-5234 | biostudies-arrayexpress
UnknownThe 2017-19 activity at Mount Agung in Bali (Indonesia): Intense unrest, monitoring, crisis response, evacuation, and eruption.
Not available
S-EPMC6586650 | biostudies-literature
TranscriptomicsHost microbiota constantly control maturation and function of microglia in the central nervous system (part 1)
As tissue macrophages of the central nervous system (CNS), microglia are critically involved in diseases of the CNS. However, it remains unknown what controls their maturation and activation under homeostatic conditions. Here we reveal significant contributions of the host microbiota to microglia ho...
ORGANISM(S): Mus musculus 
2015-05-25 | E-GEOD-62201 | biostudies-arrayexpress
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