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GenomicsChIP-Seq of fly Schneider S2 cells to investigate CID islands
The centromere-specific Histone H3-variant CENH3 (also known as CENP-A) is considered to be an epigenetic mark for establishment and propagation of centromere identity. Pulse-induction of CENH3 (Drosophila CID) in Schneider S2 cells incorporates into noncentromeric regions and generates CID islands ...
ORGANISM(S): Drosophila melanogaster 
2011-07-15 | E-MTAB-652 | biostudies-arrayexpress
TranscriptomicsAnalysis of MOF under stress conditions
We analyzed the role of MOF in primary MEFs and differentiated podocytes in response to Adriamycin. Mof was deleted in MEFs using the Cre-ERT2 trasgene, while Mof was knockdown in podocytes using shRNA infection. Samples were treated with Adriamycin for 24 hours and gene expression changes analysed....
ORGANISM(S): Mus musculus 
2015-07-10 | E-GEOD-70706 | biostudies-arrayexpress
GenomicsA transcription factor based mechanism for mouse heterochromatin formation
We identify Pax3 and Pax9 transcription factors (TFs) as important regulators of mouse heterochromatin. Simultaneous depletion of these factors results in loss of H3K9me3 from Major Satellite repeats and dramatic transcript overexpression. H3K9me3 enrichment at intergenic major satellite repeats is ...
ORGANISM(S): Mus musculus 
2012-09-16 | E-GEOD-40086 | biostudies-arrayexpress
TranscriptomicsSuv39h-dependent H3K9me3 represses intact retrotransposons in mouse embryonic stem cells
Heterochromatin is required to restrict aberrant expression of retrotransposons, but it remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h-dependent histone H3 lysine 9 trimethylation (H3K9me3) by genome-wide ChIP-sequencing in mouse embryonic stem cells (ESCs). ...
ORGANISM(S): Mus musculus 
2014-06-26 | E-GEOD-57092 | biostudies-arrayexpress
UnknownCombination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.
Not available
S-EPMC6484853 | biostudies-literature
ProteomicsVolpatti_Myopathy_P124_Lumos_VS8
This dataset consists of 9 raw MS files, acquired on Orbitrap Fusion Lumos Tribrid mass spectrometer operated in Data Dependent Acquisition mode. Cells and lysates were generated by Jonathan Volpatti. Sample processing and mass spectrometry acquisition was performed by Cassandra Wong. Data analysis...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-07-12 | MSV000089872 | MassIVE
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