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GenomicsChIP-Seq of fly Schneider S2 cells to investigate CID islands
The centromere-specific Histone H3-variant CENH3 (also known as CENP-A) is considered to be an epigenetic mark for establishment and propagation of centromere identity. Pulse-induction of CENH3 (Drosophila CID) in Schneider S2 cells incorporates into noncentromeric regions and generates CID islands ...
ORGANISM(S): Drosophila melanogaster 
2011-07-15 | E-MTAB-652 | biostudies-arrayexpress
TranscriptomicsThe Transcriptome of Nrf2-Deficient Mice in Cigarette Smoke-Induced Emphysematous Changes
Cigarette smoke (CS) imposes a strong oxidative burden on exposed tissues resulting in a severely disturbed oxidant/antioxidant balance, which in the context of chronic exposure is assumed to be a key contributor to CS-related diseases. Because of its emerging central role in orchestrating the gener...
ORGANISM(S): Mus musculus 
2010-02-27 | E-GEOD-18344 | biostudies-arrayexpress
TranscriptomicsAnalysis of MOF under stress conditions
We analyzed the role of MOF in primary MEFs and differentiated podocytes in response to Adriamycin. Mof was deleted in MEFs using the Cre-ERT2 trasgene, while Mof was knockdown in podocytes using shRNA infection. Samples were treated with Adriamycin for 24 hours and gene expression changes analysed....
ORGANISM(S): Mus musculus 
2015-07-10 | E-GEOD-70706 | biostudies-arrayexpress
UnknownControl of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells.
Not available
S-EPMC6176615 | biostudies-literature
GenomicsA transcription factor based mechanism for mouse heterochromatin formation
We identify Pax3 and Pax9 transcription factors (TFs) as important regulators of mouse heterochromatin. Simultaneous depletion of these factors results in loss of H3K9me3 from Major Satellite repeats and dramatic transcript overexpression. H3K9me3 enrichment at intergenic major satellite repeats is ...
ORGANISM(S): Mus musculus 
2012-09-16 | E-GEOD-40086 | biostudies-arrayexpress
UnknownCombined Ex Vivo 9.4T MRI and Quantitative Histopathological Study in Normal and Pathological Neocortical Resections in Focal Epilepsy.
Not available
S-EPMC4950048 | biostudies-literature
UnknownAssessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.
Not available
S-EPMC7425943 | biostudies-literature
TranscriptomicsA 50-Gene Predictor of Recurrence as a Guide to Therapy in Early-Stage Colon Cancer.
Gene expression profiles reflect unique aspects of individual biologic phenotypes and may characterize the heterogeneity of solid tumors. Using previously-described methodologies that employ DNA microarray data, a 50-gene expression profile (metagene) that predicts risk of recurrence in early stage ...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-10402 | biostudies-arrayexpress
UnknownMOF maintains transcriptional programs regulating cellular stress response.
Not available
S-EPMC4893634 | biostudies-literature
UnknownThe cardiopulmonary effects of ambient air pollution and mechanistic pathways: a comparative hierarchical pathway analysis.
Not available
S-EPMC4264846 | biostudies-literature
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