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MetabolomicsUntargeted serum metabolomics of early-life antibiotic intervention, fecal microbiota transplantation restoration, and short-term high-fat diet effects in C57BL/6 mice
This study profiles the serum metabolome in C57BL/6 mice subjected to early-life antibiotic treatment (vancomycin and gentamicin, 2 weeks), followed by fecal microbiota transplantation and a short-term high-fat diet. Serum samples were collected longitudinally and analyzed by liquid chromatography-t...
2026-08-20 | MTBLS14801 | MetaboLights
GenomicsChromatin IP sequencing of the nuclear factor HMGB1 in livers from mice after a metabolic stress either induced by a 12-week high fat diet consumption or a fasting (6hours)-refeeding (8hours) challenge.
To unveil HMGB1 DNA occupancy in livers of mice after a metabolic stress either induced by a 12-week high fat diet consumption or a fasting (6hours)-refeeding (8hours) challenge. Challenges known to generate a robust activation of hepatic lipogenesis and liver steatosis.
ORGANISM(S): Mus musculus 
2022-03-31 | E-MTAB-11543 | biostudies-arrayexpress
ProteomicsSEVERE CONSEQUENCES OF A HIGH-LIPID DIET INCLUDE HYDROGEN SULFIDE DYSFUNCTION AND DISEASE AGGRESSION IN GLIOBLASTOMA
Glioblastoma (GBM) remains among the deadliest of human malignancies, and the emergence of the cancer stem cell (CSC) phenotype represents a major challenge to durable treatment response. Because the environmental and lifestyle factors that impact CSC populations are not clear, we sought to understa...
ORGANISM(S): Homo sapiens (Human) 
2021-05-25 | PXD023685 | Pride
Metabolism Glioblastoma Diet Cancer stem cells Hydrogen sulfide 
TranscriptomicsGene expression profiling using cDNA microarray of HMGB1fl/fl and HMGB1ΔHep liver samples from mice subjected to a 12 week-HFD regimen or a Fasting/Refeeding challenge
To unveil any gene expression difference induced by hepatocyte specific-Hmgb1 gene deletion in mice after a metabolic stress either induced by a 12-week high fat diet consumption or a fasting (6hours)-refeeding (8hours) challenge. Challenges known to generate a robust activation of hepatic lipogenes...
ORGANISM(S): Mus musculus 
2022-03-31 | E-MTAB-11541 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver response to a glucose challenge in healthy and insulin resistant C57BL/6J mice
The goal of this experiment is to compare the transcriptional response to a metabolic stressor (glucose bolus) between healthy and insulin resistant mouse liver. Mice with an isogenic background (C57BL/6J mice) were fed diets for 12 weeks containing either 10 or 45% fat by energy (mainly palm oil) a...
ORGANISM(S): Mus musculus 
2012-03-21 | E-MTAB-601 | biostudies-arrayexpress
GenomicsmHF-offspring-pneumococcal-challenge-16S
Maternal diet-induced excess adiposity programs multisystem vulnerability that is unmasked by postnatal infection challenge
PRJEB113405 | ENA
TranscriptomicsIdentifying Molecular Effects of Diet through Systems Biology: Influence of Herring Diet on Sterol Metabolism and Protein Turnover in Mice
Identifying molecular effects between herring and beef diet in Ldlr-/- mice The transcriptome of the three tissues, which are liver, muscle and adipose tissue, were used for indentify the influence of diet on metabolism. Ldlr-/- mice were fed with either a beef diet or a herring diet.
ORGANISM(S): Mus musculus 
2011-01-24 | E-GEOD-22532 | biostudies-arrayexpress
TranscriptomicsRole of SIRT1 in diet-induced metabolic diseases
The purpose of this study is to investigate the role of SIRT1 in high-fat diet-induced liver steatosis and insulin resistance. SIRT1 is a nuclear enzyme that could remove an acetyl-group from target proteins by using NAD as co-substrate. Homologs of this protein in yeast and the roundworm C. elegans...
ORGANISM(S): Mus musculus 
2012-07-31 | E-GEOD-39778 | biostudies-arrayexpress
GenomicsHepatic transcript modules are predictive of atherosclerotic lesion burden after a 2-year high cholesterol, high fat diet challenge in baboons [LCLF]
Hepatic transcript modules are predictive of atherosclerotic lesion burden after a 2-year high cholesterol, high fat diet challenge in baboons [LCLF]
PRJNA587776 | ENA
GenomicsThe impact of dietary fiber supplementation on bile acid metabolism under western-diet challenge.
The impact of dietary fiber supplementation on bile acid metabolism under western-diet challenge.
PRJEB53027 | ENA
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