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TranscriptomicsNatalizumab exerts direct signaling capacity and supports a pro-inflammatory phenotype in some patients with multiple sclerosis
Natalizumab is a recombinant monoclonal antibody raised against integrin alpha-4 (CD49d). It is approved for the treatment of patients with multiple sclerosis (MS), a chronic inflammatory autoimmune disease of the CNS. Natalizumab blocks leukocyte extravasation across the blood-brain barrier by inhi...
ORGANISM(S): Homo sapiens 
2015-05-02 | E-GEOD-37783 | biostudies-arrayexpress
TranscriptomicsWhole-genome methylation profiling of monocytes and alveolar-like monocyte-derived macrophages from healthy controls and NSAID-exacerbated respiratory disease (N-ERD) patients
NSAID-exacerbated respiratory disease (N-ERD) represents a particularly severe endotype of chronic rhinosinusitis with nasal polyps (CRSwNP), which affects around 10-16% of CRSwNP patients. N-ERD is characterized by severe and refractory nasal polyposis, bronchial asthma and intolerance to non-stero...
ORGANISM(S): Homo sapiens 
2020-07-31 | E-MTAB-8065 | biostudies-arrayexpress
TranscriptomicsAmniotic fluid RNA gene expression profiling provides insights into the phenotype of Turner syndrome
Background: Turner syndrome, a common sex chromosome aneuploidy, has characteristics and malformations associated with the phenotype. Fetal amniotic fluid is a complex biological material that could contribute to the understanding Turner syndrome pathogenesis. Global gene expression analysis of Tu...
ORGANISM(S): Homo sapiens 
2014-06-13 | E-GEOD-58435 | biostudies-arrayexpress
UnknownLongitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA.
Not available
S-EPMC7670098 | biostudies-literature
UnknownRoutine Pathologic Examination of Femoral Head Specimens from Total Hip Arthroplasty May Not Be Indicated or Cost-effective: A Systematic Review.
Not available
S-EPMC9237275 | biostudies-literature
TranscriptomicsA binary redox control mode in gene expression and metabolism of plants
To analyze the impact of photosynthetic redox signals, light sources with spectral qualities that preferentially excite either Photosystem I (PSI light) or Photosystem II (PSII light) were used. The light sources have been described in (Fey et al., 2005). Strong reduction and oxidation signals were ...
ORGANISM(S): Arabidopsis thaliana 
2010-06-24 | E-GEOD-9235 | biostudies-arrayexpress
UnknownEarlier extracranial progression and shorter survival in ALK-rearranged lung cancer with positive liquid rebiopsies.
Not available
S-EPMC8182700 | biostudies-literature
UnknownDiet-induced loss of adipose hexokinase 2 correlates with hyperglycemia.
Not available
S-EPMC10017106 | biostudies-literature
UnknownDetection of TP53 Mutations in Tissue or Liquid Rebiopsies at Progression Identifies ALK+ Lung Cancer Patients with Poor Survival.
Not available
S-EPMC6356563 | biostudies-literature
UnknownDevelopmental stage of transplanted neural progenitor cells influences anatomical and functional outcomes after spinal cord injury in mice.
Not available
S-EPMC10199026 | biostudies-literature
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