Sort   by:  
 Page size 
MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
MetabolomicsThe splicing paralogues SNRPB and SNRPN control differential metabolic states

Gene duplication is a major driver of biological complexity, yet the persistence of highly similar paralogous factors suggests the existence of context-dependent functions that remain incompletely understood. Certain conserved components of the mammalian RNA processing machinery exhibit striking ...

2026-02-09 | MTBLS13877 | MetaboLights
MetabolomicsDifferential alteration of plant functions by homologous fungal candidate effectors

Rust fungi are plant pathogens that cause epidemics which threatens the production of many important plant species, such as wheat, soy, coffee and poplar. Melampsora larici-populina (Mlp) causes the poplar rust and encodes at least 1184 candidate effectors (CEs), however their functions are poorl...

2020-12-03 | MTBLS2096 | MetaboLights
MetabolomicsSimilar, but different: structurally related azelaic acid and hexanoic acid trigger differential metabolomic and transcriptomic responses in tobacco cells
BACKGROUND: Plants respond to various stress stimuli by activating an enhanced broad-spectrum defensive ability. The development of novel resistance inducers represents an attractive, alternative crop protection strategy. In this regard, hexanoic acid (Hxa, a chemical elicitor) and azelaic acid (Aza...
2018-10-17 | MTBLS559 | MetaboLights
MetabolomicsDifferential expression of Transcriptomics and Metabolomics in different developmental periods of poria cocos

Poria cocos, a traditional medicinal fungus, exhibits a wide array of biological activities. Through the integration of metabolomic and transcriptomic analyses, we have determined that the development of Poria cocos mycelia is predominantly propelled by biochemical reactions triggered by oxidativ...

2025-03-26 | MTBLS11738 | MetaboLights
MetabolomicsScreening of Differential Metabolites and Metabolic Pathway Analysis Related to Colorectal Adenoma Recurrence

Background To analyze the differences in gut metabolites between the CRA (colorectal adenoma) recurrence and non-recurrence groups, to identify characteristic metabolites and related metabolic pathways associated with recurrence, and to provide new evidence for risk stratification and interv...

2026-08-08 | MTBLS15298 | MetaboLights
MetabolomicsEvidence for quorum sensing and differential metabolite production by Ruegeria pomeroyi in response to DMSP
Microbial alteration and remineralization of organic matter in the ocean play essential roles in the carbon cycle. The impact of individual compounds as either growth substrates or infochemicals is still poorly constrained in models, particularly for organisms with relatively versatile genomes. Here...
2015-01-29 | MTBLS157 | MetaboLights
MetabolomicsIntegrated Proteomic and Metabolomic Analyses Show Differential Effects of Glucose Availability in Marine Synechococcus and Prochlorococcus

We compared changes induced by the addition of 100 nM and 5 mM glucose on the proteome and metabolome complements in Synechococcus sp. strains WH8102, WH7803, and BL107 and Prochlorococcus sp. strains MED4, SS120, and MIT9313, grown either under standard light conditions or in d...

2023-02-06 | MTBLS5462 | MetaboLights
MetabolomicsIn-depth organic mass cytometry reveals differential contents of 3-hydroxybutanoic acid at the single-cell level
Comprehensive single-cell metabolic profiling is critical for revealing phenotypic heterogeneity and elucidating the molecular mechanisms underlying biological processes. However, single-cell metabolomics remains challenging because of the limited metabolite coverage and inability to discriminate is...
2026-08-14 | MTBLS8113 | MetaboLights
MetabolomicsDivergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition
Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucity of knowledge regarding the biology of T. congole...
2021-07-20 | MTBLS2372 | MetaboLights
Sort   by:  
 Page size