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MetabolomicsThe splicing paralogues SNRPB and SNRPN control differential metabolic states

Gene duplication is a major driver of biological complexity, yet the persistence of highly similar paralogous factors suggests the existence of context-dependent functions that remain incompletely understood. Certain conserved components of the mammalian RNA processing machinery exhibit striking ...

2026-02-09 | MTBLS13877 | MetaboLights
MetabolomicsEvidence for quorum sensing and differential metabolite production by Ruegeria pomeroyi in response to DMSP
Microbial alteration and remineralization of organic matter in the ocean play essential roles in the carbon cycle. The impact of individual compounds as either growth substrates or infochemicals is still poorly constrained in models, particularly for organisms with relatively versatile genomes. Here...
2015-01-29 | MTBLS157 | MetaboLights
MetabolomicsIntegrated Proteomic and Metabolomic Analyses Show Differential Effects of Glucose Availability in Marine Synechococcus and Prochlorococcus

We compared changes induced by the addition of 100 nM and 5 mM glucose on the proteome and metabolome complements in Synechococcus sp. strains WH8102, WH7803, and BL107 and Prochlorococcus sp. strains MED4, SS120, and MIT9313, grown either under standard light conditions or in d...

2023-02-06 | MTBLS5462 | MetaboLights
MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
MetabolomicsIntegrated Proteomics and Metabolomics Analysis Reveals Differential Lipid Metabolism in HUVEC under high and low shear stress
OBJECTIVE: Atherosclerotic plaque development is closely associated with the hemodynamic forces applied to endothelial cells (EC). Among these, shear stress (SS) plays a key role in disease development since changes in flow intensity and direction could stimulate an atheroprone or athero...
2019-07-25 | MTBLS739 | MetaboLights
MetabolomicsCoordinate Regulation of Metabolite Glycosylation and Stress Hormone Biosynthesis by TT8 in Arabidopsis
Secondary metabolites play a key role in coordinating ecology and defense strategies of plants. Diversity of these metabolites arise by conjugation of core structures with diverse chemical moieties, such as sugars in glycosylation. Active pools of phytohormones, including those involved in plant str...
2016-10-03 | MTBLS129 | MetaboLights
MetabolomicsDifferential interactions of dietary EPA and DHA with the gut microbiota dictate distinct metabolic outcomes in the host

Background: Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are known to modulate host physiology, but their differential interactions with the gut microbiota and consequent host metabolic effects remain poorly understood.

Methods: We employed shotgun metagenomics, untargeted met...

2026-01-31 | MTBLS13495 | MetaboLights
MetabolomicsSynergistic regulation of Codonopsis pilosula growth and metabolism by Trichoderma, salicylic acid and methyl jasmonate
Endophytic fungi can mediate salicylic acid (SA)- and methyl jasmonate (MeJA)-related signaling in medicinal plants, thereby influencing metabolite synthesis, stress resistance, and growth development. Experimental groups comprised control, Trichoderma longibrachiatum inoculation (FG), FG+SA (FS), F...
2026-04-22 | MTBLS14304 | MetaboLights
MetabolomicsSynergistic regulation of Codonopsis pilosula growth and metabolism by Trichoderma, salicylic acid and methyl jasmonate
Endophytic fungi can mediate salicylic acid (SA)- and methyl jasmonate (MeJA)-related signaling in medicinal plants, thereby influencing metabolite synthesis, stress resistance, and growth development. Experimental groups comprised control, Trichoderma longibrachiatum inoculation (FG), FG+SA (FS), F...
2026-04-16 | MTBLS14293 | MetaboLights
MetabolomicsMetabolomic Profiling of the Striatum in Shank3 Knockout ASD Rats: Effects of Early Swimming Regulation

OBJECTIVE: This study aimed to investigate the regulatory impact of early swimming intervention on striatal metabolism in Shank3 gene knockout ASD model rats.

METHODS: Shank3 gene knockout exon 11-21 male 8-day-old SD rats were used as experimental subject...

2024-09-27 | MTBLS8577 | MetaboLights
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