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ProteomicsCP-24,879: an activity-based probe of fatty acid desaturases and related diiron lipid oxidases
: CP-24,879 inhibits fatty acid desaturase 2 (FADS2), a diiron lipid oxidase necessary for polyunsaturated fatty acid (PUFA) biosynthesis, with exceptional cellular potency (EC50 15 nM) despite its fragment-like structure. Here we demonstrate CP-24,879 is activated in cells to a reactive intermedia...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD072626 | Pride
Diiron lipid oxidases Lipid metabolism Mechanism of action Chemical proteomics Activity-based probe 
ProteomicsCP-24,879: an activity-based probe of fatty acid desaturases and related diiron lipid oxidases.
Abstract: CP-24,879 inhibits fatty acid desaturase 2 (FADS2), a diiron lipid oxidase necessary for polyunsaturated fatty acid (PUFA) biosynthesis, with exceptional cellular potency (EC50 15 nM) despite its fragment-like structure. Here we demonstrate CP-24,879 is unexpectedly activated in cells to ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD078603 | Pride
Activity probe Covalent inhibitor Chemoproteomics Oxidase Fads2 
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