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MetabolomicsMicrobiota Reprogramming Driven by 7,8-Dihydroxyflavone Potentiates Xanthine Oxidase to Mitigate Hyperuricemia
Hyperuricemia (HUA), primarily driven by xanthine oxidase (XO)-mediated uric acid production, presents substantial challenges to both human health and livestock productivity. While conventional XO inhibitors are effective in mitigating HUA, they are often linked to severe adverse effects. In this st...
2026-04-29 | MTBLS14398 | MetaboLights
MetabolomicsPolyphenolic Profiling of Plants and Edible Mushrooms to Aid Characterizing Polyphenol Oxidase Selectivity

Polyphenol oxidases are important metalloenzymes that catalyze the oxidation of polyphenols. Organisms can contain multiple isoenzymes whose possible different functionality is not understood. Moreover, their substrate preference is still unexplored, and a working hypothesis assumes their specifi...

2025-08-07 | MTBLS8782 | MetaboLights
MetabolomicsMechanistic profiling of Bifemetstrobin against the tea anthracnose pathogen and candidate evaluation of an amine oxidase target
Tea anthracnose caused by Glomerella cingulata threatens yield and quality, while resistance to legacy fungicides highlights the need for new modes of action. We characterized the antifungal activity and mechanism of bifemetstrobin against G. cingulata by combining efficacy assays with cell biology ...
2026-04-24 | MTBLS14357 | MetaboLights
MetabolomicsMechanistic profiling of Bifemetstrobin against the tea anthracnose pathogen and candidate evaluation of an amine oxidase target

Tea anthracnose caused by Glomerella cingulata threatens yield and quality, while resistance to legacy fungicides highlights the need for new modes of action. We characterized the antifungal activity and mechanism of bifemetstrobin against G. cingulata by combining efficacy assays with cell ...

2026-03-13 | MTBLS13992 | MetaboLights
MetabolomicsInhibition of diamine oxidase promotes uptake of putrescine from rat small intestine
Not available
ORGANISM(S): Rattus norvegicus 
ST000401 | MetabolomicsWorkbench
MetabolomicsSystemic impact of the expression of the mitochondrial alternative oxidase on Drosophila development
Not available
ORGANISM(S): Drosophila melanogaster 
ST002069 | MetabolomicsWorkbench
TranscriptomicsEffect of spermine oxidase overexpression on skeletal muscle mRNA expression.
For additional details see Bongers et al, Spermine Oxidase Maintains Basal Skeletal Muscle Gene Expression and Fiber Size, and Is Strongly Repressed by Conditions that Cause Skeletal Muscle Atrophy . Am J Physiol Endocrinol Metab. 2014 [under review] Bilateral tibialis anterior muscles of C57BL/6 m...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-63006 | biostudies-arrayexpress
TranscriptomicsEffects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells
Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa). Clorgyline, an MAO-A inhibito...
ORGANISM(S): Homo sapiens 
2010-07-17 | E-GEOD-17167 | biostudies-arrayexpress
ProteomicsCRK2-mediated control of ROS production by phosphorylation of the RBOHD C-terminus in Arabidopsis
Reactive oxygen species (ROS) are important messengers in eukaryotic organisms. Extracellular ROS production by NADPH oxidases in plants is triggered by receptor-like protein kinase (RLK)-dependent signaling networks. This ROS production is tightly controlled by multiple mechanisms including phospho...
ORGANISM(S): Arabidopsis Thaliana 
2020-03-27 | PXD013525 | panorama
TranscriptomicsArabidopsis GLYCOLATE OXIDASE 1 and 2 display divergent roles under conditions promoting photorespiration
Hydrogen peroxide (H2O2) can act as a signaling molecule that influences various aspects of plant growth and development, including stress signaling and cell death. To unravel the molecular mechanisms that regulate the response towards an impact of increased H2O2 levels in plant cells, we focused on...
ORGANISM(S): Arabidopsis thaliana 
2016-06-10 | E-GEOD-77170 | biostudies-arrayexpress
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