Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Effect of spermine oxidase overexpression on skeletal muscle mRNA expression.

ABSTRACT: For additional details see Bongers et al, Spermine Oxidase Maintains Basal Skeletal Muscle Gene Expression and Fiber Size, and Is Strongly Repressed by Conditions that Cause Skeletal Muscle Atrophy . Am J Physiol Endocrinol Metab. 2014 [under review] Bilateral tibialis anterior muscles of C57BL/6 mice were harvested seven days after transfection with spermine oxidase or control plasmid.

ORGANISM(S): Mus musculus

SUBMITTER: Daniel Fox 

PROVIDER: E-GEOD-63006 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy.

Bongers Kale S KS   Fox Daniel K DK   Kunkel Steven D SD   Stebounova Larissa V LV   Murry Daryl J DJ   Pufall Miles A MA   Ebert Scott M SM   Dyle Michael C MC   Bullard Steven A SA   Dierdorff Jason M JM   Adams Christopher M CM  

American journal of physiology. Endocrinology and metabolism 20141118 2

Skeletal muscle atrophy is a common and debilitating condition that remains poorly understood at the molecular level. To better understand the mechanisms of muscle atrophy, we used mouse models to search for a skeletal muscle protein that helps to maintain muscle mass and is specifically lost during muscle atrophy. We discovered that diverse causes of muscle atrophy (limb immobilization, fasting, muscle denervation, and aging) strongly reduced expression of the enzyme spermine oxidase. Important  ...[more]

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