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TranscriptomicsRNA-Seq of Aged Polg Mutator Mouse Brains
We have performed both proteomic and transcriptomic analyses of the brains of one-year old Polg mutator mice. As part of this analysis, we generated RNA-Seq data from RNA isolated from one cerebral hemisphere of these mice. mRNA levels and protein abundance levels were compared in this study. 11 sa...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-55188 | biostudies-arrayexpress
TranscriptomicsA comprehensive view of the transcriptome during development of the mouse cerebral cortex
The complexity of the mature adult brain is a result of both developmental processes and experience-dependent circuit formation. One way to look at the process of brain development is to examine gene expression changes, and previous studies have used microarrays to address this in a global manner. H...
ORGANISM(S): Mus musculus 
2013-02-10 | E-GEOD-39866 | biostudies-arrayexpress
TranscriptomicsADAR2 affects mRNA coding sequence edits but not gene expression or splicing in vivo
Adenosine deaminases (ADARs) are RNA binding proteins that bind to double stranded RNA and convert adenosine to inosine. Editing creates multiple isoforms of neurotransmitter receptors, including AMPA-subtype Glutamate channels such as Gria2 that is edited to introduce a Q to R amino acid change. ...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-70588 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of peripheral whole blood RNA following ischemic stroke
The purpose of this project was to elucidate gene expression in the peripheral whole blood of acute ischemic stroke patients to identify a panel of genes for the diagnosis of acute ischemic stroke. Peripheral blood samples were collected in Paxgene Blood RNA tubes from stroke patients who were >18 y...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-16561 | biostudies-arrayexpress
TranscriptomicsGene expression changes across multiple regions of the Parkinson’s disease brain
We have used microarrays to analyze gene expression in Parkinson’s disease (PD). We used four different brain regions, including two that are relatively affected in PD (striatum and cortex) and two that are relatively spared (cerebellum and medulla). We show that while differences between brain regi...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-28894 | biostudies-arrayexpress
TranscriptomicsNorth American Brain Expression Consortium: Laser capture microdissection of Cerebellar Purkinje Cells
Previous studies in bulk tissue suggest that there are abundant expression quantitative trait loci (eQTLs) in human brain. This sample series is of cerebellar Purkinje cells isolated using laser capture microdissection from human cases without neurological disease but of known genotypes. These data ...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-37205 | biostudies-arrayexpress
GenomicNABEC: North American Brain Expression Consortium

This study utilized neurologically normal control samples deposited in North American Brain Expression Consortium (NABEC). This top-level study, phs001300, makes available all phenotype data of the NABEC study participants.
In addition, molecular data of six sub-studies are available through...

phs001300 | dbGaP
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