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TranscriptomicsDengue virus inhibits immune responses in Aedes aegypti cells
The ability of many viruses to manipulate the host antiviral immune response often results in complex host-pathogen interactions. In order to study the interaction of dengue virus (DENV) with the Aedes aegypti immune response, we have characterized the DENV infection-responsive transcriptome of the ...
ORGANISM(S): Aedes aegypti 
2011-10-31 | E-GEOD-33274 | biostudies-arrayexpress
TranscriptomicsGenome-wide transcriptomic profiling of Anopheles gambiae hemocytes reveals pathogen-specific signatures upon bacterial challenge and Plasmodium berghei infection
Background: The mosquito Anopheles gambiae is a major vector of human malaria. Increasing evidence indicates that blood cells (hemocytes) comprise an essential arm of the mosquito innate immune response against both bacteria and malaria parasites. To further characterize the role of hemocytes in mos...
ORGANISM(S): Anopheles gambiae 
2011-10-31 | E-GEOD-33269 | biostudies-arrayexpress
TranscriptomicsTranscriptomic and functional analysis of the Anopheles gambiae salivary gland in relation to blood feeding
Background: The Anopheles gambiae salivary glands play a major role in malaria transmission and express a variety of bioactive components that facilitate blood-feeding by preventing platelet aggregation, blood clotting, vasodilatation, and inflammatory and other reactions at the probing site on the ...
ORGANISM(S): Anopheles gambiae 
2011-11-01 | E-GEOD-33385 | biostudies-arrayexpress
TranscriptomicsAnalysis of Culex quinquefasciatus responses to WNV infection
Analysis of Culex quinquefasciatus responses to West Nile virus (WNV) infection at 7 and 14 days after ingestion of infected blood in the gut and carcass tissues. Comparison of WNV-infected to non-infected carcass and gut samples.
ORGANISM(S): Culex quinquefasciatus 
2011-11-01 | E-GEOD-23045 | biostudies-arrayexpress
TranscriptomicsAnopheles gambiae immune responses to human and rodent Plasmodium parasite species
Transmission of malaria is dependent on the successful completion of the Plasmodium lifecycle in the Anopheles vector. Major obstacles are encountered in the midgut tissue, where most parasites are killed by the mosquito’s immune system. In the present study, DNA microarray analyses have been used t...
ORGANISM(S): Anopheles gambiae 
2007-08-15 | E-GEOD-8789 | biostudies-arrayexpress
TranscriptomicsBacteria- and IMD Pathway-Independent Immune Defenses against Plasmodium falciparum in Anopheles gambiae
The mosquito Anopheles gambiae uses its innate immune system to control bacterial and Plasmodium infection of its midgut tissue. The activation of potent IMD pathway-mediated anti-Plasmodium falciparum defenses is dependent on the presence of the midgut microbiota, which activate this defense system...
ORGANISM(S): Anopheles gambiae 
2013-08-10 | E-GEOD-49690 | biostudies-arrayexpress
TranscriptomicsCharacterization of the Rel2-regulated transcriptome and proteome of Anopheles stephensi identifies new anti-Plasmodium factors
Mosquitoes possess an innate immune system that is capable of limiting infection by a variety of pathogens, including the Plasmodium spp. parasites responsible for human malaria. The Anopheles immune deficiency (IMD) innate immune signaling pathway confers resistance to Plasmodium falciparum. While ...
ORGANISM(S): Anopheles stephensi 
2014-07-11 | E-GEOD-59258 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of head, midgut, carcass and ovaries of adult Anopheles gambiae mosquitoes
We conducted a genome wide survey of mosquito gene expression profiles in 4 different tissues of adult Anopheles gambiae mosquitoes. The tissues included the head, the midgut, the carcass (corresponding to the remainder of the mosquito after decapitation and midgut removal) and ovaries. Ovaries were...
ORGANISM(S): Anopheles gambiae 
2007-07-19 | E-TABM-153 | biostudies-arrayexpress
UnknownSepsis pathogenesis and outcome are shaped by the balance between the transcriptional states of systemic inflammation and antimicrobial response.
Not available
S-EPMC11604535 | biostudies-literature
ProteomicsProteomic analysis of bone marrow CD138+ cells to identify proteins associated with the response of multiple myeloma patients to commonly used therapeutic regimens.
Multiple Myeloma (MM) remains incurable; gaps in our understanding of MM molecular pathogenesis and drugs resistance mechanisms are involved in the failure of therapies to eradicate the disease. This study aims to identify proteins significantly impacting MM patients' response to commonly used thera...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-04-02 | MSV000097497 | MassIVE
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