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TranscriptomicsB lymphocyte activation induces DNA methylation reprogramming and establishes a common epigenetic signature in memory B and plasma cell compartments [gene expression profiling]
DNA methylation profiling of human B cell populations representing a developmental series before and after immune activation. The B cells are derived from inflamed tonsils. The B cells were already activated in vivo in patients, therefore there was no need to stimulate the B cells after isolation. ...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-24863 | biostudies-arrayexpress
GenomicsGenome-wide DNA methylation maps in chronic lymphocytic leukemia cells determined by next-generation sequencing
We conducted a genome-wide DNA methylation analysis in CD19+ B-cells from CLL patient and normal control samples using reduced representation bisulfite sequencing (RRBS). The methylation status of 1.8-2.3 million CpGs in the CLL genome was determined; about 45% of these CpGs were located in more tha...
ORGANISM(S): Homo sapiens 
2012-05-10 | E-GEOD-32698 | biostudies-arrayexpress
TranscriptomicsIdentification of SUUR protein binding sites in Drosophila Kc cells using DamID
Salivary gland polytene chromosomes of Drosophila melanogaster have a reproducible set of intercalary heterochromatin sites, characterized by late DNA replication, underreplicated DNA, breaks and frequent ectopic contacts. The SuUR mutation has been shown to suppress underreplication, and wild-type ...
ORGANISM(S): Drosophila melanogaster 
2007-07-04 | E-MEXP-863 | biostudies-arrayexpress
TranscriptomicsFatty Acid Amide Hydrolase regulates peripheral B cell receptor revision, polyreactivity and B1 cells in lupus
FAAH expresson is induced in Sle2 splenic B cells. Increased peripheral B cell receptor revision, or selective peripheral expansion of BCR-revised B-cells, may lead to systemic autoimmunity, and FAAH is a lupus susceptibility gene that could regulate this process in Sle2 mice. To determine the gene ...
ORGANISM(S): Mus musculus 
2015-09-17 | E-GEOD-73112 | biostudies-arrayexpress
UnknownStaphylococcus aureus DinG, a helicase that has evolved into a nuclease.
Not available
S-EPMC3270479 | biostudies-literature
TranscriptomicsRNA-seq data of ABC from Bm12-induced lupus model
Age-associated B cells (ABCs) accumulate in systemic autoimmunity, and contributes to pathogenesis. ABCs are characterized by high expression of CD11c and T-bet. As a transcription factor, T-bet cannot be labeled in live cells with antibodies, so we constructed a reporter mouse strain in which fluor...
ORGANISM(S): Mus musculus 
2023-02-16 | E-MTAB-12568 | biostudies-arrayexpress
GenomicsThe Aurora B kinase and the polycomb protein Ring1B combine to regulate active promoters in quiescent lymphocytes [ChIP-seq]
Genome-wide distribution of proteins and histone marks in CD43 negative mouse resting B cells ChIP-seq analyses of Aurora B, Ring1B, Bcx7, USP16, H3K27me3, and Ezh2 were carried out on wild-typeCD43 negative resting B cells. ChIP-seq datasets obtained from Aurora B knockout and RingiB knockout cel...
ORGANISM(S): Mus musculus 
2013-09-27 | E-GEOD-42705 | biostudies-arrayexpress
TranscriptomicsThe Aurora B kinase and the polycomb protein Ring1B combine to regulate active promoters in quiescent lymphocytes [RNA-Seq]
Expression profiling of resting B cells to classify active and silent genes based on expression levels 4 biological replicates of mRNA extracted from freshly purified mouse CD43 negative resting B cells
ORGANISM(S): Mus musculus 
2013-09-27 | E-GEOD-42704 | biostudies-arrayexpress
UnknownIntroduction of cytochrome b mutations in Saccharomyces cerevisiae by a method that allows selection for both functional and non-functional cytochrome b proteins.
Not available
S-EPMC2601669 | biostudies-literature
UnknownThe helicases DinG, Rep and UvrD cooperate to promote replication across transcription units in vivo.
Not available
S-EPMC2770101 | biostudies-literature
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