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TranscriptomicsRNA-Seq of Aged Polg Mutator Mouse Brains
We have performed both proteomic and transcriptomic analyses of the brains of one-year old Polg mutator mice. As part of this analysis, we generated RNA-Seq data from RNA isolated from one cerebral hemisphere of these mice. mRNA levels and protein abundance levels were compared in this study. 11 sa...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-55188 | biostudies-arrayexpress
ProteomicsProteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice
Mutations in leucine-rich repeat kinase 2 (LRRK2) segregate with familial Parkinson’s disease (PD) and genetic variation in LRRK2 contributes to risk of sporadic disease. Although knockout of LRRK2 or knock-in of pathogenic mutations into the mouse germline does not result in a PD phenotype, several...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-01 | PXD008531 | Pride
Membrane trafficking Proteomics Lrrk2 Protein translation Lysosomal function Genetic mouse models Parkinson’s disease 
TranscriptomicsTranscription profiling of Plasmodium falciparum after exposing drug-selected mutants to short term CQ treatment
Mutations in PfCRT confer chloroquine (CQ) resistance in P. falciparum. Point mutations in the homolog of the mammalian multidrug resistance gene (pfmdr1) can also modulate the levels of CQ response. However, parasites with the same pfcrt and pfmdr1 alleles exhibit a wide range of drug sensitivity, ...
ORGANISM(S): Plasmodium falciparum 
2008-11-06 | E-GEOD-10022 | biostudies-arrayexpress
GenomicStudy of Irish Amyotrophic Lateral Sclerosis (SIALS)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by loss of motor neurons. Epidemiological studies indicate that 2-5% of cases are familial, usually with an autosomal dominant pattern of inheritance. For a portion of these, causative genes have been...

phs000127 | dbGaP
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