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ProteomicsBlocking CXCR4+ CD4+ T cells reprograms Treg-mediated immunosuppression via modulating the Rho-GTPase/NF-κB pathway
Clinical trials have demonstrated that CXCR4 antagonists enhance the efficacy of immunotherapy in cancers by reducing regulatory T (Treg) cells, elucidating how certain mechanisms of CXCR4 in affecting Treg cells are essential for developing immunotherapeutic strategies.
ORGANISM(S): Homo Sapiens 
2024-11-25 | PXD058262 |
UnknownExperimental Study on the Modified P-V-T Model to Improve Shrinkage Prediction for Injection-Molded Semi-Crystalline Polymer.
Not available
S-EPMC12899455 | biostudies-literature
ProteomicsProteomics of Prostate Cancer Tissue Small Extracellular Vesicles Reveal Alteration of Metabolism
Prostate cancer (PCa) is a leading male malignancy worldwide, with metabolic reprogramming being a critical hallmark of its progression. Extracellular vesicles (EVs) derived from tissues directly reflect the tumor microenvironment, offering unique insights into cancer pathophysiology that are unatta...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD070089 | Pride
Tumor metabolism Prostate cancer Tissue evs Glycolysis 
ProteomicsPARP1-SNAI2 Transcription Axis Drives Resistance to PARP Inhibitor, Talazoparib
The synthetic lethal association between BRCA deficiency and poly (ADP-ribose) polymerase (PARP) inhibition supports PARP inhibitor (PARPi) clinical efficacy in BRCA-mutated tumors. PARPis also demonstrate activity in non-BRCA mutated tumors presumably through induction of PARP1-DNA trapping. Despit...
ORGANISM(S): Homo sapiens (Human) 
2022-07-08 | PXD033530 | Pride
Parp1 Drug resistance Talazoparib 
MetabolomicsAn overlooked prebiotic: beneficial effect of dietary nucleotide supplementation on gut microbiota and metabolites in senescence-accelerated mouse prone-8 mice
Nucleotides (NTs) are regulatory factors in many biological processes and play important roles in the growth, development, and metabolism of living organisms. We used senescence-accelerated mouse prone-8 (SAMP8) to investigate the effects of NTs on the gut microbiota and metabolites. And the promoti...
2022-03-21 | MTBLS4012 | MetaboLights
UnknownCorneal higher-order aberrations as key predictive indicators of axial elongation in myopic children with orthokeratology: a single-center prospective cohort study.
Not available
S-EPMC12375064 | biostudies-literature
GenomicsDirect Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors (ChIP-Seq)
Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study, we show that Bmi1, a core component of Polycomb Repressive Complex 1 (PRC1), binds direct...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-33653 | biostudies-arrayexpress
UnknownResolution of Disease Phenotypes Resulting from Multilocus Genomic Variation.
Not available
S-EPMC5335876 | biostudies-literature
UnknownmicroRNA-219-5p targets NEK6 to inhibit hepatocellular carcinoma progression.
Not available
S-EPMC7724362 | biostudies-literature
UnknownAstrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition.
Not available
S-EPMC11676029 | biostudies-literature
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