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MetabolomicsDirect infusion mass spectrometry metabolomics dataset: a benchmark for data processing and quality control
Direct-infusion mass spectrometry (DIMS) metabolomics is an important approach for characterising molecular responses of organisms to disease, drugs and the environment. Increasingly large-scale metabolomics studies are being conducted, necessitating improvements in both bioanalytical and computatio...
2022-05-16 | MTBLS79 | MetaboLights
MetabolomicsDirect on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights
MetabolomicsRapid Evaporative Ionisation Mass Spectrometry (REIMS) Provides Accurate Direct from Culture Species Identification within the Genus Candida
Members of the genus Candida, such as C. albicans and C. parapsilosis, are important human pathogens. Other members of this genus, previously believed to carry minimal disease risk, are increasingly recognised as important human pathogens, particularly because of variations in susceptibilities to wi...
2017-11-01 | MTBLS383 | MetaboLights
MetabolomicsMulti-country metabolic signature discovery for chicken health classification

INTRODUCTION: To decrease antibiotic resistance, their use as growth promoters in the agricultural sector has been largely abandoned. This may lead to decreased health due to infectious disease or microbiome changes leading to gut inflammation.

OBJECTIVES: ...

2023-08-08 | MTBLS5065 | MetaboLights
ProteomicsProjDIA: Fragment-Bin Projection Scoring and Calibrated Confidence for Direct Infusion DIA Proteomics
Direct-infusion shotgun proteome analysis (DI-SPA) increases throughput by removing liquid chromatography, but the resulting DIA spectra are highly multiplexed and difficult to interpret. This dataset was generated to evaluate ProjDIA, a computational workflow for direct-infusion DIA proteomics. Pro...
ORGANISM(S): Homo sapiens (Human) 
2026-04-02 | PXD076477 | Pride
Mcf7 Proteomics Projdia Direct infusion Dia Species entrapment Di-spa Hela Label-free quantification 
MetabolomicsAn Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid phenotyping for large epidemiological studies to reveal the detailed associati...
2024-02-02 | MTBLS4461 | MetaboLights
MetabolomicsA Metabolic Profiling Strategy for the Dissection of Plant Defense against Fungal Pathogens (DI-MS assays)
Here we present a metabolic profiling strategy employing direct infusion Orbitrap mass spectrometry (MS) and gas chromatography-mass spectrometry (GC/MS) for the monitoring of soybean's (Glycine max L.) global metabolism regulation in response to Rhizoctonia solani infection in a time-course. Key el...
2014-11-15 | MTBLS117 | MetaboLights
MetabolomicsUsing network analysis to discern compositional patterns in ultrahigh resolution mass spectrometry data of dissolved organic matter

RATIONALE: Marine dissolved organic matter (DOM) has long been recognized as a large and dynamic component of the global carbon cycle. Yet, DOM is chemically varied and complex and these attributes present challenges to researchers interested in addressing questions about the rol...

2016-10-31 | MTBLS366 | MetaboLights
MetabolomicsWolbachia modulation of lipid metabolism in Aedes albopictus mosquito cells
Certain strains of the intracellular endosymbiont Wolbachia can strongly inhibit or block the transmission of viruses such as dengue by Aedes mosquitoes, and the mechanisms responsible are still not well understood. Direct infusion and liquid chromatography FT-ICR mass spectrometry based lipidomicse...
MTBLS210 | MetaboLights
ProteomicsPrecision-Engineered Nano-Electrospray Emitters Enhance Ionization Efficiency for Trap-Assisted Direct Infusion Mass Spectrometry: Application in Plasma Alzheimer’s Disease Proteomics
Shotgun direct infusion mass spectrometry (DI-MS) enables high-throughput proteomics. Yet, its performance critically depends on nanospray emitter quality. We present here precision-engineered nanospray emitters with an optimized 4-degree emitter tip angle, designed for sensitive, reproducible, user...
ORGANISM(S): Homo sapiens (Human) 
2025-07-31 | PXD061620 | Pride
Direct infusion mass spectrometry Alzheimer’s disease Emitters Di-ms Plasma Plasma proteomics 
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