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ProteomicsDirect-to-biology: Accelerated E3 ligase modulator discovery
Quatintative analysis of the effects of the E14 compound on the proteome of MM.1S cells.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046752 | Pride
Mm.1s Degraders Multiple myeloma 
UnknownA direct-to-biology high-throughput chemistry approach to reactive fragment screening.
Not available
S-EPMC8457371 | biostudies-literature
ProteomicsExpedited SARS-CoV-2 MPro inhibitor discovery through a modular, 'direct-to-biology' approach
Reactive fragment (RF) screening has emerged as an efficient method for ligand discovery across the proteome, irrespective of a target’s perceived tractability. To date, however, the efficiency of subsequent optimisation campaigns has largely been low-throughput, constrained by the need for synthesi...
ORGANISM(S): Homo sapiens (Human) 
2024-12-20 | PXD056098 | Pride
Covalent drug discovery Chemoproteomics Sars-cov-2 mpro 
GenomicsA Systems Biology Approach To Disentangle the Direct and Indirect Effects of Global Transcription Factors on Gene Expression in Escherichia coli
A Systems Biology Approach To Disentangle the Direct and Indirect Effects of Global Transcription Factors on Gene Expression in Escherichia coli
PRJNA802728 | ENA
UnknownAccelerating PROTACs Discovery Through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry.
Not available
S-EPMC11234393 | biostudies-literature
UnknownDeconvoluting low yield from weak potency in direct-to-biology workflows with machine learning.
Not available
S-EPMC10953487 | biostudies-literature
UnknownExpanding the reaction toolbox for nanoscale direct-to-biology PROTAC synthesis and biological evaluation.
Not available
S-EPMC11664481 | biostudies-literature
UnknownDirect-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery.
Not available
S-EPMC10730884 | biostudies-literature
UnknownDirect-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation.
Not available
S-EPMC9290060 | biostudies-literature
TranscriptomicsGene expression profiles of canine osteosarcoma
Pulmonary metastasis continues to be the most common cause of death in osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has not significantly changed in over 20 years. Further understanding of the mechanisms of metastasis and resistance for this aggressive pediatr...
ORGANISM(S): Canis lupus familiaris 
2010-05-08 | E-GEOD-16087 | biostudies-arrayexpress
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