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TranscriptomicsSingle cell derived clonal analysis of human glioblastoma links functional and genomic heterogeneity
Single cell derived clones were extracted from four glioblastoma tumors using fluorescence activated cell sorting with CD15 and CD133 markers. Unsorted bulk tumors were also derived. Genotyping and copy number analysis was carried out for each tumor separately. Patient blood was used as control for ...
ORGANISM(S): Homo sapiens 
2015-01-03 | E-MTAB-2694 | biostudies-arrayexpress
TranscriptomicsSingle cell derived clonal analysis of human glioblastoma links functional and genomic heterogeneity
Single cell derived clones were extracted from four glioblastoma tumors using fluorescence activated cell sorting with CD15 and CD133 markers. Unsorted bulk tumors were also derived. Gene expression analysis of clones of tumor GBM-482 involved comparison between TMZ resistant (n=5) and sensitive (n=...
ORGANISM(S): Homo sapiens 
2015-01-03 | E-MTAB-2693 | biostudies-arrayexpress
UnknownBRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma.
Not available
S-EPMC4356711 | biostudies-literature
TranscriptomicsEpigenetic determinants of self-renewal in glioblastoma
We over-expressed an epigenetic regulator in a glioblastoma (GBM) primary culture from an adult patient. These GBM cells have cancer stem cell phenotypes, as they have self-renewal properties and tumor initiation potential when transplanted in immunocompromised mice. An epigenetic regulator (ER) w...
ORGANISM(S): Homo sapiens 
2015-11-11 | E-GEOD-63296 | biostudies-arrayexpress
TranscriptomicsGene expression data from PNU 96415E treated human glioblastoma derived neural stem cells (GNS)
Glioblastomas grow in a rich neurochemical mileu, but targeting neurochemical signaling as a potential therapeutic avenue for these incurable tumors has been underexplored. Thus, we probed patient derived glioblastoma stem cells with a focused library of neurochemicals, to identify new therapeutic ...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-62714 | biostudies-arrayexpress
TranscriptomicsHigh-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
The ability to perturb genes in human cells is crucial for elucidating gene function and holds great potential for finding therapeutic targets for diseases such as cancer. To extend the catalog of human core and context- dependent fitness genes, we have developed a high-complexity second-generation ...
ORGANISM(S): Homo sapiens 
2015-11-25 | E-GEOD-75189 | biostudies-arrayexpress
TranscriptomicsSox2 signature in SHH medulloblastomas
Affymetrix Human Gene 1.1 ST Array profiling of 83 primary SHH-driven medulloblastoma samples. Total RNA was extracted from primary medulloblastoma samples and hybridized to Affymetrix Human Gene 1.1 ST Arrays (24-Array Plates) according to the manufacturer's instructions.
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-50765 | biostudies-arrayexpress
TranscriptomicsIntrinsic glioma subtypes in EORTC 26951 (part 4)
Background: Intrinsic glioma subtypes (IGS) are molecularly similar tumors that can be identified based on unsupervised gene-expression analysis. Here, we have evaluated the clinical relevance of these subtypes within EORTC26951, a randomized phase III clinical trial investigating adjuvant procarbaz...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-43115 | biostudies-arrayexpress
TranscriptomicsIntrinsic glioma subtypes in EORTC 26951 (part 2)
Background: Intrinsic glioma subtypes (IGS) are molecularly similar tumors that can be identified based on unsupervised gene-expression analysis. Here, we have evaluated the clinical relevance of these subtypes within EORTC26951, a randomized phase III clinical trial investigating adjuvant procarbaz...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-43113 | biostudies-arrayexpress
TranscriptomicsIntrinsic glioma subtypes in EORTC 26951 (part 3)
Background: Intrinsic glioma subtypes (IGS) are molecularly similar tumors that can be identified based on unsupervised gene-expression analysis. Here, we have evaluated the clinical relevance of these subtypes within EORTC26951, a randomized phase III clinical trial investigating adjuvant procarbaz...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-43114 | biostudies-arrayexpress
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