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Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS640 | MetaboLights
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS674 | MetaboLights
Cellular self-organization orchestrates ferroptosis propagation
Neocortical tau propagation is a mediator of clinical heterogeneity in Alzheimer’s disease
Specialized chromatin exists at centromeres and must be precisely transmitted during DNA replication. The mechanisms involved in the propagation of these structures remain elusive. Fission yeast centromeres are composed of two chromatin domains: the central CENP-ACnp1 kinetochore domain and flanking...
ORGANISM(S): Schizosaccharomyces pombe 
Efavirenz and Fexofenadine ameliorates the propagation of alpha-synuclein
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation [scRNA-seq]
Self-organization generates cellular patterns that guide morphogenesis, but how it regulates collective cell fate remains underexplored. We show that cellular self-organization constrains the propagation of ferroptosis, an iron-dependent form of oxidative cell death that can otherwise spread as unbo...
ORGANISM(S): Homo sapiens 
2026-10-15 | GSE344231 | GEO
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation [bulk RNA-seq]
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