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ProteomicsDual-Optimized Surface Hydrophobicity and Rigidity Determines Protein Corona Absorption and Composition on Orally Delivered Nanoparticles Treating Colitis
Disease-specific protein corona adsorbed on nanocarriers critically determines their in vivo delivery efficiency. Given that macrophages can orchestrate inflammation resolution and mucosa repair, they are regarded as promising therapeutic targets in colitis. Here, we reveal that by altering the phys...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-01-21 | PXD071199 | Pride
Colitis Rigidity Hydrophobicity Oral Disease-specific protein corona 
ProteomicsDual-Optimized Surface Hydrophobicity and Rigidity Determines Protein Corona Absorption and Composition on Orally Delivered Nanoparticles Treating Colitis
Disease-specific protein corona adsorbed on nanocarriers critically determines their in vivo delivery efficiency. Given that macrophages can orchestrate inflammation resolution and mucosa repair, they are regarded as promising therapeutic targets in colitis. Here, we reveal that by altering the phys...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-01-21 | PXD071116 | Pride
Colitis Rigidity Hydrophobicity Oral Disease-specific protein corona 
ProteomicsMass Spectrometry-Based Top-Down Proteomics for Proteoform Profiling of Protein Corona
The protein corona, a layer of biomolecules—primarily proteins—that adsorb to nanoparticle (NP) surfaces in biological fluids, critically affects NP safety and their therapeutic and diagnostic functions. Additionally, the protein corona effectively reduces proteome complexity and the dynamic range o...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD060784 | Pride
Top-down proteomics Mass spectrometry Nanomedicine Protein corona 
ProteomicsStructuring lipid nanoparticles, DNA, and protein corona into stealth bionanoarchitectures for in vivo gene delivery
Lipid nanoparticles (LNPs) play a crucial role in addressing genetic disorders, and cancer, and combating pandemics such as COVID-19 and its variants. Yet, in contrast remarkable achievements in siRNA and mRNA delivery, the ability of LNPs to effectively encapsulate large-size DNA molecules remains ...
ORGANISM(S): Homo sapiens (Human) 
2024-10-02 | PXD054751 | Pride
Protein corona Lipid nanoparticles Dna 
UnknownDisease-specific protein corona formed in pathological intestine enhances the oral absorption of nanoparticles.
Not available
S-EPMC10501873 | biostudies-literature
ProteomicsDeep Plasma Proteome Profiling by Modulating Single Nanoparticle Protein Corona with Small Molecules
The protein corona, a dynamic biomolecular layer that forms on nanoparticle (NP) surfaces upon exposure to biological fluids is emerging as a valuable diagnostic tool for improving plasma proteome coverage analyzed by liquid chromatography-mass spectrometry (LC-MS/MS). Here, we show that spiking sma...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-03-07 | MSV000094257 | MassIVE
ProteomicsNano-omics Enables Plasma-to-Tumour Tissue Integrated Proteomics for Biomarker Discovery in Glioblastoma
The dismal survival of patients with glioblastoma (GB) has only marginally improved over the past two decades, underscoring the urgent need for new technologies to advance early detection and disease monitoring strategies. Despite the promise of 'liquid biopsies’, no blood-based biomarkers have yet ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-03-11 | PXD060393 | Pride
Protein corona Proteomics Neuro-oncology Early detection Liquid-biopsy Brain cancer Biomarkers 
TranscriptomicsGenome-wide LOH and DNA copy number alteration in HPV-neg OSCC and their associations with disease-specific survival
Oral squamous cell carcinoma (OSCC) is associated with high case-fatality. To gain insight into the complexity of OSCC and to identify potential chromosomal changes that may be associated with OSCC mortality, we examined paired DNA from peripheral blood and tumor cells to assess genome-wide LOH and ...
ORGANISM(S): Homo sapiens 
2016-03-23 | E-GEOD-68717 | biostudies-arrayexpress
UnknownProtein Corona Influences Cell-Biomaterial Interactions in Nanostructured Tissue Engineering Scaffolds.
Not available
S-EPMC4978190 | biostudies-literature
UnknownSmall molecule modulation of protein corona for deep plasma proteome profiling.
Not available
S-EPMC11544298 | biostudies-literature
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