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GenomicsMatrix rigidity and cardiac reprogramming
Matrix rigidity and cardiac reprogramming
PRJNA517614 | ENA
ProteomicsDual-Optimized Surface Hydrophobicity and Rigidity Determines Protein Corona Absorption and Composition on Orally Delivered Nanoparticles Treating Colitis
Disease-specific protein corona adsorbed on nanocarriers critically determines their in vivo delivery efficiency. Given that macrophages can orchestrate inflammation resolution and mucosa repair, they are regarded as promising therapeutic targets in colitis. Here, we reveal that by altering the phys...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-01-21 | PXD071116 | Pride
Colitis Rigidity Hydrophobicity Oral Disease-specific protein corona 
ProteomicsMorphological and proteomic analyses in petioles rigidity: evidence towards phenotypic plasticity in sacred lotus for aquatic environment
Very little is known about the mechanism controlling petiole rigidity in sacred lotus (Nelumbo nucifera Gaertn.). To investigate the mechanism controlling the lotus petiole rigidity, morphological and proteomic analyses were performed. Anatomically, there is a great variation between the petioles of...
ORGANISM(S): Nelumbo nucifera (Sacred lotus) 
2021-07-29 | PXD009136 | Pride
Proteomics Sacred lotus Petiole rigidity Cell wall Lignin biosynthesis 
TranscriptomicsMatrix rigidity and cardiac reprogramming
Direct cardiac reprogramming from fibroblasts holds great potential for disease modeling, drug screening, and regeneration. However, cardiac reprogramming remains inefficient in vitro, and induced cardiomyocytes (iCMs) generated in vitro are less mature than those in vivo, suggesting undefined bioph...
ORGANISM(S): Mus musculus 
2020-08-28 | GSE125811 | GEO
GenomicsTissue rigidity mechano-priming microglia cytoskeleton-nucleus interplays with biochemical signals to amplify neuroinflammatory responses
Tissue rigidity mechano-priming microglia cytoskeleton-nucleus interplays with biochemical signals to amplify neuroinflammatory responses
PRJNA1212526 | ENA
GenomicsTranscriptomic analysis of engineered myometrial tissues with varied tissue architecture and matrix rigidity
Transcriptomic analysis of engineered myometrial tissues with varied tissue architecture and matrix rigidity
PRJNA975811 | ENA
ProteomicsDual-Optimized Surface Hydrophobicity and Rigidity Determines Protein Corona Absorption and Composition on Orally Delivered Nanoparticles Treating Colitis
Disease-specific protein corona adsorbed on nanocarriers critically determines their in vivo delivery efficiency. Given that macrophages can orchestrate inflammation resolution and mucosa repair, they are regarded as promising therapeutic targets in colitis. Here, we reveal that by altering the phys...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-01-21 | PXD071199 | Pride
Colitis Rigidity Hydrophobicity Oral Disease-specific protein corona 
OtherTissue rigidity mechano-priming microglia cytoskeleton-nucleus interplays with biochemical signals to amplify neuroinflammatory responses
Microglia play a pivotal role in modulating the pathophysiology of the central nervous system, including disease progression and injury repair. While the microenvironmental factors governing microglial activation are well understood, the impact of biophysical cues, such as tissue mechanics, remains ...
ORGANISM(S): Mus musculus 
2026-09-06 | GSE287382 | GEO
GenomicsEffects of ECM rigidity on normal and keloid dermal fibroblasts
Effects of ECM rigidity on normal and keloid dermal fibroblasts
PRJNA1033633 | ENA
TranscriptomicsTranscriptomic analysis of engineered myometrial tissues with varied tissue architecture and matrix rigidity
We report the use of RNA-seq for transcriptional analysis of engineered myometrial tissues cultured on hydrogels with varied matrix rigidity and tissue alignment.
ORGANISM(S): Homo sapiens 
2023-12-20 | GSE233288 | GEO
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