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MetabolomicsPhysiological and Molecular Dissection of Daily Variance in Exercise Capacity
Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exerc...
2019-04-07 | MTBLS145 | MetaboLights
MetabolomicsDissection of two routes to naïve pluripotency using different kinase inhibitors
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
MetabolomicsDissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by loss-of-function mutations in PKD1 or PKD2. Increased glycolysis is a prominent feature of the disease, but how it impacts on other metabolic pathways is unknown. Here, we present an analysis of mouse Pkd1 mutant ce...
2019-06-07 | MTBLS677 | MetaboLights
MetabolomicsA Metabolic Profiling Strategy for the Dissection of Plant Defense against Fungal Pathogens (DI-MS assays)
Here we present a metabolic profiling strategy employing direct infusion Orbitrap mass spectrometry (MS) and gas chromatography-mass spectrometry (GC/MS) for the monitoring of soybean's (Glycine max L.) global metabolism regulation in response to Rhizoctonia solani infection in a time-course. Key el...
2014-11-15 | MTBLS117 | MetaboLights
MetabolomicsA Metabolic Profiling Strategy for the Dissection of Plant Defense against Fungal Pathogens (GC-MS assay)
Here we present a metabolic profiling strategy employing direct infusion Orbitrap mass spectrometry (MS) and gas chromatography-mass spectrometry (GC/MS) for the monitoring of soybean's (Glycine max L.) global metabolism regulation in response to Rhizoctonia solani infection in a time-course. Key el...
2014-11-15 | MTBLS118 | MetaboLights
MetabolomicsCross-species dissection of saline-related genes by genetically deciphering a euryhaline microalga Chlorella sp.

MEM25 and FACHB-9 respectively represent salt-tolerant and freshwater species of the genus Chlorella. By setting salinity of 35 and 105 as the high and low salinity conditions for MEM25, and salinity of 0 and 35 as the high and low salinity conditions for FACHB-9, we measured the metabolome data....

2025-12-01 | MTBLS13425 | MetaboLights
MetabolomicsComprehensive dissection of primary metabolites in response to diverse abiotic stress in barley at seedling stage
Not available
ORGANISM(S): Hordeum vulgare L. 
ST001648 | MetabolomicsWorkbench
MetabolomicsMicrobiome network remodeling drives soil lipid metabolism under safflower cropping systems at different sites: An omics-based dissection
This study investigated the effects of three planting pattern–location combinations (PLMEs) on safflower rhizosphere soil microbiota and metabolic functions: soybean-safflower rotation at Chenghai (CH), tobacco–safflower rotation at Longpan (ZYHY), and apple orchard intercropping at Lijiang(LJ). Eac...
2026-07-22 | MTBLS15129 | MetaboLights
MetabolomicsMulti-omics dissection of Trametes versicolor CS05-mediated defense enhancement in Crocus sativus under Fusarium oxysporum corm rot stress

Saffron (Crocus sativus) is a high-value crop prized in culinary and pharmaceutical applications for its nutritional and therapeutic properties. However, corm rot caused by Fusarium oxysporum severely compromises yield and quality. Here, we isolated F. oxysporum strain CSP01 from diseased corms a...

2026-06-01 | MTBLS14647 | MetaboLights
UnknownCurrent state and future directions of genomic medicine in aortic dissection: A path to prevention and personalized care.
Not available
S-EPMC9258522 | biostudies-literature
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