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TranscriptomicsGlobal analysis of metastasis-associated gene expression in the primary cultures from clinical specimens of ccRCC
Metastatic clear cell renal cell carcinoma (ccRCC) has a poor prognosis and unpredictable course and there are no molecular markers that reliably predict ccRCC metastasis. In this study, specimens from 84 patients with ccRCC were directly cultured in vitro. The primary cultures from 38 of 94 specime...
ORGANISM(S): Homo sapiens 
2008-08-27 | E-GEOD-11072 | biostudies-arrayexpress
TranscriptomicsA compact VEGF signature associated with distant metastases and poor outcomes
Results When compared with each other, primary tumors and regional metastases showed statistically indistinguishable gene expression patterns. Supervised analyses comparing patients with distant metastases versus primary tumors or regional metastases showed that the distant metastases were distinct...
ORGANISM(S): Homo sapiens 
2009-03-31 | E-GEOD-3521 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cohort of human cutaneous primary melanomas associated with a distant metastasis free survival
Identification of genomic characteristics in a cohorte of human cutaneous primary melanoma associated with a distant metastasis free survival.
ORGANISM(S): Homo sapiens 
2007-04-01 | E-TABM-1 | biostudies-arrayexpress
ProteomicsPhosphatase POPX2 exhibits dual regulatory functions in cancer metastasis
Cancer metastasis is a complex mechanism involving multiple processes. In an earlier study, we reported that the levels of serine/threonine phosphatase POPX2were positively correlated with cancer cell motility through modulating MAPK signaling. Surprisingly, here we found that POPX2 knockdown cells ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080801 | MassIVE
ProteomicsIntegrated Multi-Omics Landscape of non-small cell lung cancer with distant metastasis
we collected BALF from patients with metastatic and non-metastatic NSCLC to isolate exosomes, which were then characterized by nanoparticle tracking analysis (NTA) and transmission electron microscopy (TEM), followed by comprehensive metabolomic and proteomic analysis.
ORGANISM(S): Homo Sapiens 
2025-03-13 | PXD061819 |
TranscriptomicsWhole Genome Characterization of Circulating Tumor Cells Identifies Novel Prognostic Genomic Alterations in Melanoma Metastasis
Circulating tumor cells (CTCs) are critical in the development of distant organ tumor metastasis, and are associated with advanced cancer stage and poor patient outcome. Here, we present the first genome-wide nucleotide-level characterization of CTCs. Our single-nucleotide polymorphism (SNP) analysi...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-43934 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human kidney samples to discover gene signatures of progression and metastasis in renal cell cancer
In order to address the progression, metastasis, and clinical heterogeneity of renal cell cancer (RCC), transcriptional profiling with oligonucleotide microarrays (22,283 genes) was done on 49 RCC tumors, 20 non-RCC renal tumors, and 23 normal kidney samples. Samples were clustered based on gene exp...
ORGANISM(S): Homo sapiens 
2009-04-28 | E-GEOD-15641 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis identifies TUBB2A as a novel protein biomarker for prediction of distant metastatic breast cancer
Metastasis of breast cancer to other distant organs is fatal to patients. However, few studies have revealed biomarkers associated with distant metastatic breast cancer. Furthermore, the inability of current biomarkers such as HER2, ER and PR, in accurately differentiating between distant metastatic...
ORGANISM(S): Homo sapiens (Human) 
2020-06-05 | PXD016061 | Pride
Formalin-fixed paraffin-embedded (ffpe) tissue Distant metastatic breast cancer Tandem mass tag (tmt) Quantitative proteomics Biomarkers 
TranscriptomicsSPR509: Lung metastasis
Determine gene expression differences between normal, metastatic and non-metastatic mouse lung tissue. Priming of the organ-specific premetastatic sites is thought to be an important yet incompletely understood step during metastasis. In this study, we show that the metastatic tumors we examined ove...
ORGANISM(S): Mus musculus 
2014-11-06 | E-GEOD-62817 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of breast cancer distant metastasis based on outcome over time and identification of pathway activities of late relapse
Previous reports have described the use of microarrays to assess the molecular classification of human breast cancers and defined new subgroups based on gene expression that are relevant to patient management through their ability to predict metastatic relapse and survival relapse. However, differen...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-MTAB-949 | biostudies-arrayexpress
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