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ProteomicsDetermination of disulfide bridges of human PGAP4 protein
To determine disulfide bonds of human PGAP4 protein
ORGANISM(S): Homo sapiens (Human) 
2018-01-30 | PXD008137 | Pride
Lc-msms Disulfide bridges Pgap4 
ProteomicsIntramolecular disulfide bridges in Voltage-Dependent Anion Channel 2 (VDAC2) protein from Rattus norvegicus revealed by high resolution mass spectrometry.
Voltage-Dependent Anion Channel isoforms (VDAC1, VDAC2, VDAC3) are relevant component of the outer mitochondrial membrane and play crucial role in cellular processes, in regulation of metabolism and in survival pathways. Recently, we reported the characterization of the oxidation pattern of cysteine...
ORGANISM(S): Rattus rattus (Black rat) 
2024-06-16 | PXD044041 | Pride
High-resolution mass spectrometry  intramolecular disulfide bridges  rattus voltage-dependent anion selective channel isoform 2 (rvdac2)  cysteine redox state  structural characterization. 
ProteomicsOnline electrochemical reduction of both inter- and intramolecular disulfide bridges in immunoglobulins
Cysteine disulfide bridges can be reduced by chemical methods, like an incubation with DTT. However, reduction with an electrochemical method has also been demonstrated. Electrochemical reduction can be implemented online, after LC separation and before mass spectrometry. For the study of antibody m...
ORGANISM(S): Homo sapiens (Human) 
2022-05-27 | PXD021649 | Pride
Electrochemical reduction  disulfide  top-down  antibody 
ProteomicsFast and Accurate Disulfide Bridge Detection
Recombinant expression of proteins, propelled by therapeutic antibodies, has evolved into a multi-billion-dollar industry. Essential here is quality control assessment of critical attributes such as sequence fidelity, proper folding, and post-translational modifications (PTMs). Errors can lead to di...
ORGANISM(S): Homo sapiens (Human) 
2024-04-08 | PXD046855 | Pride
Faims Disulfide Ethcd Mab Scrambling 
UnknownDisulfide Bridges: Bringing Together Frustrated Structure in a Bioactive Peptide.
Not available
S-EPMC4850350 | biostudies-literature
UnknownHuman β-defensin 4 with non-native disulfide bridges exhibit antimicrobial activity.
Not available
S-EPMC4364940 | biostudies-literature
UnknownResidual Dipolar Couplings for Resolving Cysteine Bridges in Disulfide-Rich Peptides.
Not available
S-EPMC6987419 | biostudies-literature
UnknownAbsence of calcium-sensing receptor basal activity due to inter-subunit disulfide bridges.
Not available
S-EPMC11045811 | biostudies-literature
ProteomicsStructural characterization of intra- and intermolecular disulfide bonds in Voltage-Dependent Anion Channel 3 (VDAC3) protein from Rattus norvegicus by high-resolution mass spectrometry
Voltage-Dependent Anion Channels, the most abundant proteins of the mitochondrial outer membrane, are responsible for exchange of ions and metabolites between cytosol and mitochondria. They participate in the control of glycolytic metabolism through interaction with numerous enzymes and play a key r...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-09-08 | PXD064110 | Pride
High-resolution mass spectrometry  intra- and intermolecular disulfide bonds  rattus voltage-dependent anion selective channel isoform 3 (rvdac3)  cysteine redox state  structural characterization 
UnknownA Single-Molecule Strategy to Capture Non-native Intramolecular and Intermolecular Protein Disulfide Bridges.
Not available
S-EPMC9136921 | biostudies-literature
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