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ProteomicsIon channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies
Targeted protein degradation or downregulation (TPD/TPDR) mediated by induced recruitment of an endogenous E3 ubiquitin ligase to a substrate is a disruptive paradigm for developing therapeutics. However, <2% of ~600 E3 ligases have been exploited for this modality, and efficacy for multi-subunit me...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD069051 | Pride
Hek293 cells Nedd4-2 Divalent nanobody Ion channels 
UnknownDivalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists.
Not available
S-EPMC10082178 | biostudies-literature
UnknownIon channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies.
Not available
S-EPMC11160594 | biostudies-literature
UnknownA synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection.
Not available
S-EPMC8324831 | biostudies-literature
UnknownExperimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins.
Not available
S-EPMC9731471 | biostudies-literature
UnknownFunctional characterization and discovery of modulators of SbMATE, the agronomically important aluminium tolerance transporter from Sorghum bicolor.
Not available
S-EPMC5740117 | biostudies-literature
GenomicsDetection of genomic G-quadruplexes in living cells using a small artificial protein
Detection of genomic G-quadruplexes in living cells using a small artificial protein
PRJNA551290 | ENA
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