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Proteomicsmouse Nedd4-2 KO and control tissue
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by patchy scarring of the distal lung with limited therapeutic options and poor prognosis. Here, we show that conditional deletion of the ubiquitin ligase Nedd4-2 in lung epithelial cells in adult mi...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-20 | PXD011120 | Pride
Nedd4-2 
ProteomicsStructural basis of ubiquitin ligase Nedd4-2 autoinhibition and regulation by calcium and 14-3-3 proteins
Nedd4-2 E3 ligase regulates Na+ homeostasis by ubiquitinating various channels and membrane transporters, including the epithelial sodium channel ENaC. In turn, Nedd4-2 dysregulation leads to various conditions, including electrolytic imbalance, respiratory distress, hypertension, and kidney disease...
ORGANISM(S): Homo sapiens (Human) 
2025-05-12 | PXD058899 | Pride
Saxs Calcium Protein-protein interaction H/d exchange Cryo-em Nedd4-2 14-3-3 proteins 
ProteomicsPRM detection of NEDD4-2 in human IPF and control tissue
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by patchy scarring of the distal lung with limited therapeutic options and poor prognosis. Here, we show that conditional deletion of the ubiquitin ligase Nedd4-2 in lung epithelial cells in adult mi...
ORGANISM(S): Homo sapiens (Human) 
2020-03-20 | PXD011129 | Pride
Nedd4-2 Ipf 
ProteomicsIdentifying novel NEDD4-2 interacting proteins
NEDD4-2 is an E3 ubiquitin ligase involved in the regulation of several membrane proteins. This project was designed to identify new NEDD4-2-regulated substrates in the mouse cortical collecting duct cell line.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-25 | PXD063842 | Pride
Nedd4-2 
ProteomicsIon channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies
Targeted protein degradation or downregulation (TPD/TPDR) mediated by induced recruitment of an endogenous E3 ubiquitin ligase to a substrate is a disruptive paradigm for developing therapeutics. However, <2% of ~600 E3 ligases have been exploited for this modality, and efficacy for multi-subunit me...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD069051 | Pride
Hek293 cells Nedd4-2 Divalent nanobody Ion channels 
ProteomicsMouse Nedd4-2 and control with Pirfenidone
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by patchy scarring of the distal lung with limited therapeutic options and poor prognosis. Here, we show that conditional deletion of the ubiquitin ligase Nedd4-2 in lung epithelial cells in adult mi...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-20 | PXD011119 | Pride
Pirfenidone Nedd4-2 
ProteomicsNedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity
Nedd4-2 is an E3 ubiquitin ligase in which missense mutation is related to familial epilepsy, indicating its critical role in regulating neuronal network activity. However, Nedd4-2 substrates involved in neuronal network function have yet to be identified. Using mouse lines lacking Nedd4-1 and Nedd4...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-28 | PXD046450 | Pride
Ubiquitin Protein homeostasis Isobaric labeling Synaptic membranes 
UnknownDietary sodium modulates nephropathy in Nedd4-2-deficient mice.
Not available
S-EPMC7244563 | biostudies-literature
UnknownKir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron.
Not available
S-EPMC6230743 | biostudies-literature
UnknownDeletion of Nedd4-2 results in progressive kidney disease in mice.
Not available
S-EPMC5686353 | biostudies-literature
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