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GenomicsMus musculus strain:Diversity Outbred
Diversity Outbred Liver RNASeq
PRJNA356251 | ENA
TranscriptomicsATAC-Seq of Diversity Outbred mouse embryonic stem cells
We measured genome-wide chromatin accessibility of embryonic stem cells derived from Diversity Outbred mice. We cultured cells in media with LIF + GSK3-beta inhibitor CHIR99021.
ORGANISM(S): Mus musculus 
2020-08-13 | E-MTAB-8759 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Diversity Outbred mouse embryonic stem cells
We measured genome-wide gene expression of embryonic stem cells derived from Diversity Outbred mice. We cultured cells in media with LIF + GSK3-beta inhibitor CHIR99021. All lines were passage 3-8 when RNA was collected. We obtained RNA-Seq from technical replicate cultures for three cell lines.
ORGANISM(S): Mus musculus 
2020-08-13 | E-MTAB-7728 | biostudies-arrayexpress
UnknownMt10 Vaccine Protects Diversity Outbred Mice from CVB3 Infection by Producing Virus-Specific Neutralizing Antibodies and Diverse Antibody Isotypes.
Not available
S-EPMC10975958 | biostudies-literature
ProteomicsSample multiplexing-based targeted pathway proteomics with real-time analytics reveals the impact of genetic variation on protein expression
Targeted proteomics enables hypothesis-driven research by measuring the cellular expression of protein cohorts related by function, disease, or class after perturbation. Here, we present a pathway-centric approach and an assay builder resource for targeting entire pathways of proteins selected from ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2022-08-11 | MSV000090110 | MassIVE
TranscriptomicsRNA-Seq of hippocampus in Diversity Outbred mice
To understand the genetic regulation of gene expression and patterns of gene co-expression, we sequenced the transcriptome of the hippocampus of 258 Diversity Outbred (DO) mice of both sexes. DO mice (fourth and fifth generations of outcrossing) were sacrificed between 6-8 weeks of age and hippocamp...
ORGANISM(S): Mus musculus 
2019-05-01 | E-MTAB-7637 | biostudies-arrayexpress
Proteomics,MultiomicsDefining the effects of genetic variation on a proteome-wide scale
Genetic variation governs protein expression through both transcriptional and post-transcriptional processes. To investigate this relationship, we combined a multiplexed, mass spectrometry-based method for protein quantification with an emerging mouse model harboring extensive genetic variation fro...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-11-08 | MSV000081696 | MassIVE
ProteomicsArchitecture of the outbred brown fat proteome defines regulators of metabolic physiology
Obesity is a polygenic disorder with variable penetrance in the general population. Brown adipose tissue (BAT) is a major regulator of energy expenditure and metabolic physiology due to a specialized proteome that orchestrates futile metabolic cycles, which could be leveraged to treat obesity. Howev...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-08 | PXD036947 | Pride
Diversity outbred Qtl Physiology Metabolic disease Network Proteome Obesity Phenotype 
GenomicsATAC-Seq of Diversity Outbred mouse embryonic stem cells
ATAC-Seq of Diversity Outbred mouse embryonic stem cells
PRJEB36566 | ENA
TranscriptomicsRNA-seq alignment to individualized genomes
The source of most errors in RNA sequencing (RNA-seq) read alignment is in the repetitive structure of the genome and not with the alignment algorithm. Genetic variation away from the reference sequence exacerbates this problem causing reads to be assigned to the wrong location. We developed a metho...
ORGANISM(S): Mus musculus 
2014-06-10 | E-GEOD-45684 | biostudies-arrayexpress
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