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UnknownOxidative DNA Damage, Inflammatory Signature, and Altered Erythrocytes Properties in Diamond-Blackfan Anemia.
Not available
S-EPMC7768356 | biostudies-literature
UnknownAddiction to DUSP1 protects JAK2V617F-driven polycythemia vera progenitors against inflammatory stress and DNA damage, allowing chronic proliferation.
Not available
S-EPMC6756199 | biostudies-literature
TranscriptomicsTranscriptome analysis of JAK2wt and JAK2V617F+ iPSCs and iPSC-derived CD34+ progenitor-enriched cultures, either inflammatory cytokines treated or untreated.
PV-patient specific and control healthy individual-derived iPSCs were upon differentiation for 9 days into CD34+ hematopoietic progenitors treated with IFNγ, TNFα and TGFβ1 or untreated and used for transcriptome analysis. This dataset shows presence of cell-autonomous and strong non-cell autonomous...
ORGANISM(S): Homo sapiens 
2020-12-03 | E-MTAB-7693 | biostudies-arrayexpress
UnknownDelayed hemoglobin switching and perinatal neocytolysis in mice with gain-of-function erythropoietin receptor.
Not available
S-EPMC5083035 | biostudies-literature
UnknownNovel homozygous VHL mutation in exon 2 is associated with congenital polycythemia but not with cancer.
Not available
S-EPMC3976221 | biostudies-literature
UnknownMLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells.
Not available
S-EPMC4124133 | biostudies-literature
Unknownβ-Thalassemia due to intronic LINE-1 insertion in the β-globin gene (HBB): molecular mechanisms underlying reduced transcript levels of the β-globin(L1) allele.
Not available
S-EPMC4993193 | biostudies-literature
UnknownRole of DNA Damage Response in Suppressing Malignant Progression of Chronic Myeloid Leukemia and Polycythemia Vera: Impact of Different Oncogenes.
Not available
S-EPMC7226398 | biostudies-literature
TranscriptomicsDNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-induced Leukemogenesis in vivo
Activation of the MLL-ENL-ERtm oncogene initiates aberrant proliferation of myeloid progenitors. Here, we show induction of a fail-safe mechanism mediated by the DNA damage response (DDR) machinery that results in activation of the ATR/ATM-Chk1/Chk2-p53/p21 checkpoint and cellular senescence at earl...
ORGANISM(S): Mus musculus 
2012-04-21 | E-GEOD-35038 | biostudies-arrayexpress
UnknownGermline Jak2-R1063H mutation interferes with normal hematopoietic development and increases risk of thrombosis and leukemic transformation.
Not available
S-EPMC12589134 | biostudies-literature
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