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ProteomicsGenome-wide RNAi Screening Identifies pseudouridine synthase DKC1 promotes CRC proliferation through regulating ribosomal proteins expression
Colorectal cancer (CRC) with high rate of mortality is one of the most commonly diagnosed cancers in worldwide. Advanced colorectal cancer is often accompanied by malignant proliferation of tumor cells. Further researches on colorectal cancer proliferation to find new targets and develop new therape...
ORGANISM(S): Homo sapiens (Human) 
2021-02-08 | PXD018103 | Pride
Proteomics Dkc1 Colorectal cancer 
GenomicsSingle cell transcriptomics of hepatostellate organoids derived from DKC1 A353V mutant and DKC1 A353V corrected iPSCs
Single cell transcriptomics of hepatostellate organoids derived from DKC1 A353V mutant and DKC1 A353V corrected iPSCs
PRJNA780948 | ENA
GenomicsDKC1 promotes colorectal cancer progression and therapy resistance by dysregulating sphingolipid biosynthesis
DKC1 promotes colorectal cancer progression and therapy resistance by dysregulating sphingolipid biosynthesis
PRJNA1373032 | ENA
GenomicsDKC1 downregulation by transient transfection of UT-SCC12A cells with siDKC1
DKC1 downregulation by transient transfection of UT-SCC12A cells with siDKC1
PRJNA856134 | ENA
GenomicsDKC1: a robust prognostic factor and potential therapeutic target in Multiple Myeloma
DKC1: a robust prognostic factor and potential therapeutic target in Multiple Myeloma
PRJNA1332719 | ENA
Genomics
DKC1 CLIP
PRJNA809673 | ENA
Genomics
DKC1 2CIMPL
PRJNA809674 | ENA
TranscriptomicsDKC1 promotes colorectal cancer progression and therapy resistance by dysregulating sphingolipid biosynthesis
Higher expression of Dyskerin Pseudouridine Synthase 1 (DKC1) associates with poor prognosis in colorectal cancer (CRC) patients. However, the mechanism associated with DKC1 upregulation, and its functional significance in disease pathogenesis and therapeutic resistance remains largely unexplored. H...
ORGANISM(S): Homo sapiens 
2026-02-27 | GSE312326 | GEO
TranscriptomicsDKC1: a robust prognostic factor and potential therapeutic target in Multiple Myeloma
Multiple Myeloma (MM) is an incurable plasma cell malignancy. Dyskerin pseudouridine synthase 1 (DKC1), a nucleolar protein, is essential for RNA modification and cellular homeostasis, yet its role in MM remains unclear. Here, we report that elevated DKC1 expression independently predicted poor outc...
ORGANISM(S): Homo sapiens 
2026-04-15 | GSE308784 | GEO
TranscriptomicsDKC1 downregulation by transient transfection of UT-SCC12A cells with siDKC1
We have investigated the functional effects of DKC1 downregulation in cSCC cells, and unveiled new roles for DKC1 in the metastatic process: metabolism and invasiveness. Transcriptional, proteomic and metabolomic analyses showed that reduced DKC1 levels in cSCC cells resulted in both an activation o...
ORGANISM(S): Homo sapiens 
2023-01-17 | GSE207542 | GEO
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