Sort   by:  
 Page size 
ProteomicsGFP-DLC1 interactome in MCF7 breast cancer cells
The Rho GTPase activating protein Deleted in Liver Cancer 1 (DLC1) is frequently downregulated through genetic and epigenetic mechanisms in various malignancies, leading to aberrant Rho GTPase signaling and thus facilitating cancer progression. The aim of this project was to identify novel interacti...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD027186 | Pride
Breast cancer Mcf7 Dlc1 Rhogap 
ProteomicsPhosphoproteome analysis of DLC1 in breast cancer
Deleted in Liver Cancer-1 (DLC1), a member of the RhoGAP family of proteins, functions as a tumor suppressor in several cancers including breast cancer. However, its clinical relevance is unclear in breast cancer. In this study, expression of DLC1 was correlated with prognosis using publicly availab...
ORGANISM(S): Homo sapiens (Human) 
2018-10-04 | PXD008220 | Pride
Phosphoproteome Dlc1 Breast cancer 
TranscriptomicsEffect of silencing DLC1 (Deleted in Liver Cancer 1) in Human Umbilical Vein Endothelial Cells (HUVEC)
We observed that silencing DLC1 in HUVEC made them more resilient to certain types of cell death. We wondered what type of mechanism is protecting the cells from death induced after long term confluence culture. HUVEC were transduced with the control (pLKO) or silencing vectors shDLC1#3 or #7 (TRCN0...
ORGANISM(S): Homo sapiens 
2017-12-28 | E-MTAB-5263 | biostudies-arrayexpress
TranscriptomicsDLC1 Suppresses Breast Cancer Bone Metastasis
The skeleton is the most common metastasis site of breast cancer cells and the molecular underpinning of this process is incompletely understood. The tumor suppressor gene deleted in liver cancer-1 (DLC1) encodes a multi-domain protein including a RhoGTPase activating protein (RhoGAP) domain and has...
ORGANISM(S): Homo sapiens 
2013-12-19 | E-GEOD-46214 | biostudies-arrayexpress
TranscriptomicsDLC1 Suppresses Breast Cancer Bone Metastasis
The skeleton is the most common metastasis site of breast cancer cells and the molecular underpinning of this process is incompletely understood. The tumor suppressor gene deleted in liver cancer-1 (DLC1) encodes a multi-domain protein including a RhoGTPase activating protein (RhoGAP) domain and has...
ORGANISM(S): Homo sapiens 
2013-12-19 | GSE46214 | GEO
ProteomicsDetermination of Trunk Neural Crest Cell Fate and Susceptibility to Splicing Perturbation by the DLC1-SF3B1-PHF5A splicing complex
How the ubiquitously expressed splicing factors specifically regulate neural crest (NC) development and enhance their vulnerability to splicing perturbations remain poorly understood. Here, we show that NC-specific DLC1, partnering with SF3B1-PHF5A splicing complex, are crucial for determining avian...
ORGANISM(S): Gallus Gallus 
2025-06-09 | PXD064804 |
UnknownDLC1 negatively regulates angiogenesis in a paracrine fashion.
Not available
S-EPMC2970702 | biostudies-literature
GenomicsDetermination of Trunk Neural Crest Cell Fate and Susceptibility to Splicing Perturbation by the DLC1-SF3B1-PHF5A splicing complex
Determination of Trunk Neural Crest Cell Fate and Susceptibility to Splicing Perturbation by the DLC1-SF3B1-PHF5A splicing complex
PRJNA1274480 | ENA
UnknownFunctional antagonism between CagA and DLC1 in gastric cancer.
Not available
S-EPMC9376073 | biostudies-literature
UnknownCooperation of DLC1 and CDK6 affects breast cancer clinical outcome.
Not available
S-EPMC4291472 | biostudies-literature
Sort   by:  
 Page size