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GenomicsNovel insights into Emx2 and Dmrta2 cooperation during cortex development and evidence for Dmrta2 function in choroid plexus
Novel insights into Emx2 and Dmrta2 cooperation during cortex development and evidence for Dmrta2 function in choroid plexus
PRJNA1234605 | ENA
ProteomicsNovel insights into Emx2 and Dmrta2 cooperation during cortex development and evidence for Dmrta2 function in choroid plexus
Early dorsal telencephalon development is coordinated by an interplay of transcription factors that exhibit a graded expression pattern in neural progenitors. How they function together to orchestrate cortical development remains largely unknown. The Emx2 and Dmrta2 genes encode TFs that are express...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-04 | PXD056238 | Pride
Emx2 Cerebral cortex Tf cooperation Hydrocephaly Dmrta2 
ProteomicsNovel insights into Emx2 and Dmrta2 cooperation during cortex development and evidence for Dmrta2 function in choroid plexus-part 2
Early dorsal telencephalon development is coordinated by an interplay of transcription factors that exhibit a graded expression pattern in neural progenitors. How they function together to orchestrate cortical development remains largely unknown. The Emx2 and Dmrta2 genes encode TFs that are express...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-04 | PXD061688 | Pride
Emx2 Cerebral cortex Tf cooperation Hydrocephaly Dmrta2 
UnknownNovel Insights into Emx2 and Dmrta2 Cooperation during Cortex Development and Evidence for Dmrta2 Function in the Choroid Plexus.
Not available
S-EPMC12225600 | biostudies-literature
UnknownDMRTA2 supports glioma stem-cell mediated neovascularization in glioblastoma.
Not available
S-EPMC10954651 | biostudies-literature
GenomicsNovel insights into Emx2 and Dmrta2 cooperation during cortex development and evidence for Dmrta2 function in choroid plexus
Early dorsal telencephalon development is coordinated by an interplay of transcription factors that exhibit a graded expression pattern in neural progenitors. How they function together to orchestrate cortical development remains largely unknown. The Emx2 and Dmrta2 genes encode TFs that are express...
ORGANISM(S): Mus musculus 
2025-06-01 | GSE291657 | GEO
TranscriptomicsTranscriptome profiling of Dmrta2 KO neural progenitor cells derived from mouse embryonic stem cells (mESCs)
The goal of this study was to use RNAseq to identify genes that are differentially expressed by cortical neural progenitor cells upon loss of Dmrta2. Datasets were gathered from two separate mESC lines, Dmrta2-/- and a control Dmrta2-flox/flox
ORGANISM(S): Mus musculus 
2017-06-01 | GSE90827 | GEO
UnknownThe doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.
Not available
S-EPMC5514752 | biostudies-literature
TranscriptomicsGene expression affected by loss-of- or gain-of-function of Dmrt3/Dmrta2 in the dorsomedial telencephalon
We then examined the mutant mice that lack both Dmrt3 and Dmrta2 alleles, and found the size of the medial cortex including the hippocampus and the cortical hem was significantly reduced in mutant brains .To further investigate how Dmrt3 and Dmrta2 are involved in the development of the medial corte...
ORGANISM(S): Mus musculus 
2019-08-03 | GSE83639 | GEO
ProteomicsEvidence that Dmrta2 acts through repression of Pax6 in cortical patterning and identification of a mutation crucial for DNA recognition associated with microcephaly in human
Dmrta2 (also designated Dmrt5) is a transcriptional regulator expressed in cortical progenitors in a caudomedial high/rostrolateral low gradient with important roles at different steps of cortical development. Dmrta2 has been suggested to act in cortex development mainly by differential suppression ...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-30 | PXD062221 | Pride
Cerebral cortex Neural progenitor Neurogenesis Transcription factor. 
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