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MetabolomicsWe characterize the anti-phage function of a type IV TA system, ShosTA toxin-antitoxin system provides phage defense via DNA damage and repair
Widespread in bacteria and archaea, Toxin-antitoxin (TA) systems have been recently demonstrated to function in phage defense. Here we characterize the anti-phage function of a type IV TA system, ShosTA. Using structural and biochemical approaches, we show that ShosT couples phosphoribosyltransferas...
2025-02-17 | MTBLS11212 | MetaboLights
TranscriptomicsInvolvement of a chromatin remodeling complex in damage tolerance during DNA replication
ATP-dependent chromatin remodeling complexes have been shown to participate in DNA replication in addition to transcription and DNA repair. However, the mechanisms of their involvement in DNA replication remain unclear. Here, we reveal a specific function of the yeast INO80 chromatin remodeling comp...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-20 | E-GEOD-18570 | biostudies-arrayexpress
TranscriptomicsRoles for the Transcription Elongation Factor NusA in Both DNA Repair and Damage Tolerance Pathways in Escherichia coli
Here we report our observations that have led us to propose that the transcription elongation factor NusA promotes a novel class of transcription-coupled repair (TCR) in addition to its previously proposed role in recruiting translesion synthesis (TLS) DNA polymerases to gaps encountered during tran...
ORGANISM(S): Escherichia coli 
2010-07-14 | E-GEOD-22829 | biostudies-arrayexpress
MetabolomicsPeroxin Pex8 couples stress responses, antifungal tolerance and virulence regulation in Candida albicans

Candida albicans, a World Health Organization critical-priority fungal pathogen, represents the predominant cause of candidemia. Therapeutic failure is sometimes driven by antifungal tolerance, a phenotype distinct from resistance, whose underlying mechanisms remain incompletely defined....

2026-03-12 | MTBLS13170 | MetaboLights
TranscriptomicsDNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity
DNA replication is sensitive to damage in the template. To bypass lesions and complete replication, cells activate recombination-mediated (error-free) and translesion synthesis-mediated (error-prone) DNA damage tolerance pathways. Crucial for error-free DNA damage tolerance is template switching, wh...
ORGANISM(S): Saccharomyces cerevisiae 
2014-01-28 | E-GEOD-46260 | biostudies-arrayexpress
MetabolomicsIntegrated transcriptome and metabolome analysis reveals the regulatory mechanism underlying fluoride tolerance in XSKD silkworm strain
XueSong KD (XSKD) is a fluoride-tolerant Bombyx mori strain that grows normally under long-term fluoride exposure, whereas its molecular tolerance mechanism remains elusive. Herein, we performed combined transcriptomic and untargeted metabolomic profiling using pre-molt fourth-instar XSKD larvae fed...
2026-07-07 | MTBLS14966 | MetaboLights
MetabolomicsMulti-omics-identified StAPR3 enhances potato Cd tolerance and tuber quality via sulfur metabolism and glutathione redox homeostasis

Cadmium (Cd) in agricultural soils inhibits potato growth, disrupts tuber development, and causes Cd accumulation in edible tubers, threatening food safety. Here, we determined the EC50 of Cd in potato, which induced oxidative stress and chloroplast damage. Transcriptomic and metabolomic co-analy...

2026-09-04 | MTBLS15532 | MetaboLights
UnknownDNA lesions proximity modulates damage tolerance pathways in Escherichia coli.
Not available
S-EPMC5934622 | biostudies-literature
MetabolomicsThe Cd-tolerance of pepper (Capsicum annuum L.) is linked with rhizosphere bacterial community composition and rhizosphere soil metabolites profiles

Cadmium (Cd) poses a serious threat to plant growth, so the selection and breeding of Cd-tolerant pepper cultivars is an effective method to reduce Cd hazards. This study identified C. annuum G03 as a Cd-tolerant cultivar, evidenced by its superior leaf physiological activity under Cd stress comp...

2025-10-23 | MTBLS13200 | MetaboLights
UnknownRFWD3 and translesion DNA polymerases contribute to PCNA modification-dependent DNA damage tolerance.
Not available
S-EPMC9348633 | biostudies-literature
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