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GenomicsGenomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation
DNA methylation is an epigenetic modification associated with transcriptional repression of promoters and is essential for mammalian development. Establishment of DNA methylation is mediated by the de novo DNA methyltransferases DNMT3A and DNMT3B, whereas DNMT1 ensures maintenance of methylation thr...
ORGANISM(S): Mus musculus 
2015-01-20 | E-GEOD-57411 | biostudies-arrayexpress
GenomicsGenomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation
This SuperSeries is composed of the SubSeries listed below. DNA methylation is an epigenetic modification associated with transcriptional repression of promoters and is essential for mammalian development. Establishment of DNA methylation is mediated by the de novo DNA methyltransferases DNMT3A and...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-57413 | biostudies-arrayexpress
GenomicsGenomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation
DNA methylation is an epigenetic modification associated with transcriptional repression of promoters and is essential for mammalian development. Establishment of DNA methylation is mediated by the de novo DNA methyltransferases DNMT3A and DNMT3B, whereas DNMT1 ensures maintenance of methylation thr...
ORGANISM(S): Mus musculus 
2015-01-20 | E-GEOD-57412 | biostudies-arrayexpress
GenomicsDe novo methylaton of the unmethylated K. phaffii genome by human DNA methyltransferases (DNMTs) [BiSulfite-seq]
De novo methylaton of the unmethylated K. phaffii genome by human DNA methyltransferases (DNMTs) [BiSulfite-seq]
PRJNA578170 | ENA
GenomicsDe novo methylaton of the unmethylated K. phaffii genome by human DNA methyltransferases (DNMTs) [RNA-seq]
De novo methylaton of the unmethylated K. phaffii genome by human DNA methyltransferases (DNMTs) [RNA-seq]
PRJNA578165 | ENA
GenomicsDNA methyltransferases are complementary in maintaining DNA methylation in embryonic stem cells
DNA methyltransferases are complementary in maintaining DNA methylation in embryonic stem cells
PRJNA860964 | ENA
GenomicsMaintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases (Dnmt3ab KO ChIP-Seq)
During mammalian development DNA methylation patterns need to be reset in primordial germ cells (PGC) and preimplantation embryos. However, many retro-transposons and imprinted genes are resistant to such global epigenetic reprogramming via hitherto undefined mechanisms. Here, we report that some of...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-47878 | biostudies-arrayexpress
TranscriptomicsMaintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases (Dnmt3ab KO RNA-Seq)
During mammalian development DNA methylation patterns need to be reset in primordial germ cells (PGC) and preimplantation embryos. However, many retro-transposons and imprinted genes are resistant to such global epigenetic reprogramming via hitherto undefined mechanisms. Here, we report that some of...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-47883 | biostudies-arrayexpress
Methylation profilingDNA methyltransferases are complementary in maintaining DNA methylation in embryonic stem cells
To investigate the cooperative function DNMTs in the maintenance of DNA methylation at the ICRs, we established mutant ES clones lacking three major DNA methyltransferases (DNMTs).
ORGANISM(S): Mus musculus 
2022-10-21 | GSE208759 | GEO
UnknownMolecular modeling studies of the novel inhibitors of DNA methyltransferases SGI-1027 and CBC12: implications for the mechanism of inhibition of DNMTs.
Not available
S-EPMC3636198 | biostudies-literature
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